Urbifen 50

• Rheumatoid arthritis
• Osteoarthritis
• Ankylosing spondylitis
• Frozen shoulder
• Low back pain
• Sprains and strains
• Dysmenorrhoea
• Migraine
• Postoperative analgesia
• Dental pain
• Sore throat

Flurbiprofen is a cyclooxygenase inhibitor which has potent anti-inflammatory effects with antipyretic and analgesic activity. It inhibits prostaglandin and thromboxane biosynthesis. It inhibits vasodilatation and also prevents the sensitization of pain fibers by prostaglandins.

Adult Dose:

• 150-200 mg daily in divided doses, increased to 300 mg daily in acute conditions.
• Dysmenorrhoea: Initially 100 mg, then 50-100 mg every 4-6 hours. Max: 300 mg daily.
• Rheumatoid Arthritis, Osteoarthritis: 200-300 mg/day divided q6-12hr PO.

Child Dose:

• <12 years: Not recommended.

Renal Dose:

• Severe Impairment: Not recommended.

* Use as directed by the registered physician

Common Side Effects:

• Dyspepsia
• Nausea
• Vomiting
• Constipation
• Diarrhea
• Peripheral edema
• Dizziness
• Tinnitus
• Blurred vision

Serious Side Effects: Peptic ulcer, hemorrhage and perforation.

Use in Pregnancy: May be unsafe during pregnancy. Animal studies have shown harmful effects. Your doctor will weigh the benefits and risks.

Precautions:

• Caution in patients with peptic ulcer or recent gastrointestinal hemorrhage.
• Caution with anticoagulant therapy, diuretic therapy and history of heart failure/hypertension.
• Avoid in patients with aspirin hypersensitivity.
• Avoid in pregnancy (3rd trimester) and lactation.

Overdose: There is no specific antidote. Best treated by gastric lavage and correction of serum electrolytes if necessary.

Storage: Store in cool and dry place, away from light and out of children's reach.