Valestra 2

• Hormone Replacement Therapy: Used for treatment of menopause symptoms such as hot flushes, night sweats and mood swings.
• Vaginal Atrophy: Used for treatment of vaginal dryness and itching during menopause.
• Osteoporosis Prevention: Used for prevention of bone loss in postmenopausal women.
• Metastatic Breast Cancer: Used for palliative treatment in selected patients.
• Prostate Cancer: Used for palliative treatment.

Adult Dose (Oral):

• Vulvar and Vaginal Atrophy in Menopause: 1-2 mg PO once daily for 3 weeks, followed by 1 week off
• Prevention of osteoporosis: 0.5 mg PO once daily for 3 weeks, followed by 1 week off
• Metastatic breast cancer: 10 mg PO q8hr for 3 months
• Prostate cancer: 1-2 mg PO q8hr for >=3 months

Elderly and Hepatic impairment: Dose adjustment may be needed.

Common Side Effects:

• Headache
• Nausea
• Breast pain
• Abdominal cramp
• Bloating
• Vaginal spotting
• Vomiting
• Hair loss

Precautions:

• Estradiol does not usually affect your ability to drive.
• Prescribed as part of HRT to relieve symptoms of menopause.
• Take at the same time every day.
• Inform your doctor if you experience any unusual vaginal bleeding, discharge or vaginal discomfort.
• May increase risk of breast cancer; have regular breast examinations.
• Stop taking and inform doctor immediately if unexplained swelling and pain in limbs, shortness of breath, chest pain, or changes in vision occur.