৳ 321.21/unit
Pack: ৳ 321.21
৳ 321.21/unit
Pack: ৳ 321.21
At a glance
Vancomycin is an antibiotic used in the treatment of severe bacterial infections in hospitalized patients. It is effective against infections of the respiratory tract, urinary tract, skin and soft tissues, bones and joints, heart, blood and others.
Indications
- Severe bacterial infections
- Staphylococcal infections
- Endocarditis
- Pneumonia
- Osteomyelitis
- Septicemia
- Soft tissue infections
Pharmacology
Vancomycin binds tightly to D-alanyl-D-alanine portion cell wall precursor causing blockage of glycopeptide polymerisation which produces immediate inhibition of cell wall synthesis and secondary damage to the cytoplasmic membrane.
Dosage
Adult Dose (IV):
- Severe staphylococcal or other Gram-positive infections, Endocarditis: 500 mg every 6 hours, infused over at least 60 min; or 1 g every 12 hours, infused over at least 100 min
- Normal renal function: 2 gm daily (in 4 or 2 divided doses)
- Renal impairment: Dosage adjustment based on creatinine clearance
Child Dose (IV):
- 1 month: 10 mg/kg/day divided every 6 hours; individual dose not to exceed 1 g
- Children: 40 mg/kg total daily dose in 4 divided doses
Side effects
Common Side Effects:
- Breathlessness
- Decreased blood pressure
- Wheezing
- Renal injury
- Flushing
- Injection site pain, swelling, and redness
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies show harmful effects; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Does not usually affect ability to drive
- Finish the full course even if you feel better; stopping early may make infection harder to treat
- Administer slowly via IV drip
- Regular monitoring of kidney function and hearing may be done
- Regular blood tests may be needed to check drug levels
- Consult doctor if pregnant or breastfeeding
Overdose effects
Symptoms: Hypotension, wheezing, dyspnoea, urticaria, pruritus, flushing, chest pain and muscle spasm.
Treatment: Supportive care; poorly removed by haemodialysis or peritoneal dialysis.
Storage conditions
Store in a cool and dry place, protected from light. Keep out of reach of children.