৳ 15/unit
Pack: ৳ 15
৳ 15/unit
Pack: ৳ 15
At a glance
Varenicline Tartrate is a prescription medicine used to quit smoking by reducing the craving for a cigarette and the irritable feeling that occurs when you stop smoking. It works by blocking nicotine effect on the brain and this suppresses enjoyment while smoking or the urge to smoke.
Indications
- Quitting smoking
Pharmacology
Varenicline binds with high affinity and selectivity at α4β2 neuronal nicotinic acetylcholine receptors. Electrophysiology studies in vitro and neurochemical studies in vivo have shown that varenicline binds to α4β2 neuronal nicotinic acetylcholine receptors and stimulates receptor-mediated activity, but at a significantly lower level than nicotine. Varenicline blocks the ability of nicotine to activate α4β2 receptors.
Dosage
Adult Dose (Oral):
- Begin 1 week before the quit date
- Days 1-3: 0.5 mg once daily
- Days 4-7: 0.5 mg twice daily
- Day 8 to end of treatment: 1 mg twice daily
- If successful after 12 weeks, continue another 12 weeks at 1 mg twice daily
- Severe renal impairment (CrCl <30 mL/min): 0.5 mg once daily initially; may increase to 0.5 mg twice daily; ESRD: not to exceed 0.5 mg once daily
Side effects
Common Side Effects:
- Nausea
- Headache
- Insomnia
- Abnormal dreams
- Nasopharyngitis
- Constipation
- Flatulence
- Vomiting
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies show harmful effects; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May decrease alertness; do not drive
- Counselling should be done to increase chances of successful quit attempt
- Stop taking and inform doctor if sudden mood and behavior changes or suicidal thoughts occur
- Inform doctor if history of heart diseases, fits (seizures), or other mental disorders
- Increased effects of alcohol have been reported; reduce alcohol consumption
- Discontinue and notify doctor if somnambulism occurs
Overdose effects
Symptoms: Nausea, headache, insomnia.
Treatment: Supportive care.
Storage conditions
Keep below 30°C, away from light and moisture; keep out of reach of children.