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At a glance

This combination, is a standard triple therapy regimen, is indicated in the eradication of H. pylori in active chronic gastritis, duodenal and gastric ulcers.

Indications
  • Eradication of H. pylori in active chronic gastritis, duodenal and gastric ulcers
Pharmacology

Vonoprazan inhibits H+, K+-ATPase in gastric parietal cells, blocking gastric acid production. Amoxicillin is an antibacterial drug. Clarithromycin is a macrolide antimicrobial drug.

Dosage

Adult Dose (Oral):

  • Vonoprazan 20 mg, Amoxicillin 1000 mg, Clarithromycin 500 mg
  • Each given twice daily (morning and evening, 12 hours apart), with or without food, for 14 days
Side effects

Common Side Effects:

  • Dysgeusia
  • Diarrhea
  • Vulvovaginal candidiasis
  • Headache
  • Abdominal pain
  • Hypertension
  • Nasopharyngitis
Use in pregnancy

Use in Pregnancy: Based on findings from animal studies and observational studies in pregnant women with use of clarithromycin, use of this triple pack is not recommended in pregnant women.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Serious and occasionally fatal hypersensitivity reactions (e.g., anaphylaxis) have been reported
  • Discontinue at the first signs or symptoms of SCAR
  • Evaluate if diarrhea occurs with this pack
  • Avoid in patients with known QT prolongation
  • Discontinue if signs and symptoms of hepatitis occur
Overdose effects

Symptoms: Limited information.

Treatment: Consult with doctor immediately.

Storage conditions

Do not store above 30°C. Keep in a dry place. Protect from light and keep out of the reach of children.

Vonoprazan + Amoxicillin + Clarithromycin — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.