Celiprolol Hydrochloride

Celiprolol Hydrochloride belongs to a group of medicines called beta-blockers. It is used for treating hypertension (high blood pressure) and angina (heart-related chest pain). It reduces blood pressure and helps in preventing future heart attack and stroke. Celiprolol Hydrochloride should be taken in the dose and duration as advised by your doctor. The dose will depend on what you are being treated for and how you respond to the medicine. You should always take it as it has been prescribed for you. It should be taken on an empty stomach and try to take it at the same time each day. You should keep taking it even if you feel well. You are still getting the benefits. If you stop taking it suddenly, your condition may worsen. The most common side effects are nausea, headache, fatigue, slow heart rate, palpitations, and breathlessness. You may also experience stomach pain, constipation, dizziness and diarrhea. Talk to your doctor if the side effects bother you or will not go away. Most are short-lived and improve as your body gets used to the medicine. You should not use this medicine if you have asthma, very slow or uneven heartbeats or a serious heart condition, including heart failure. Talk to your doctor before taking it if you have kidney or liver problems or chronic obstructive pulmonary disease (COPD). In terms of lifestyle, alcohol may affect the way this medicine works and should be avoided. You should not drive if this medicine makes you feel dizzy. Ask your doctor whether it is safe to take this medicine if you are pregnant or breastfeeding.

Celiprolol Hydrochloride is a beta blocker that works specifically on the heart. It works by slowing down the heart rate and makes the heart more efficient at pumping blood around the body.

• Hypertension (high blood pressure)
• Angina (heart-related chest pain)

Celiprolol is a vasoactive beta-1 selective adrenoceptor antagonist with partial beta-2 agonist activity. The beta-2 agonist activity is thought to account for its mild vasodilating properties. It lowers blood pressure in hypertensive patients at rest and on exercise. The effects on heart rate and cardiac output are dependent on the pre-existing background level of sympathetic tone. Under conditions of stress such as exercise, celiprolol attenuates chronotropic and inotropic responses to sympathetic stimulation. However, at rest minimal impairment of cardiac function is seen.

Celiprolol is a cardioselective β-blocker. It exhibits intrinsic sympathomimetic and direct vasodilator activity.

Adult Dose (Oral):

(After 2-4 weeks, your doctor may increase the dose to 400 mg once daily if needed)

Renal Dose: CrCl 15-40 ml/min: 100-200 mg/day; CrCl <15 ml/min: Avoid use.

Hepatic Dose: Low doses are recommended in patients with liver problems.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Celiprolol Hydrochloride is to be taken on an empty stomach. Take the tablets preferably first thing in the morning, one hour before food or two hours after food.

If you miss a dose of Celiprolol Hydrochloride, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common Side Effects (may affect up to 1 in 10 people):

• Dizziness or light headedness
• Weakness
• Fainting especially when standing up from a lying position
• Skin rashes
• Excessive itching
• Nausea
• Headache
• Fatigue
• Constipation
• Diarrhea

Serious Side Effects: Allergic reaction (rash, swallowing or breathing problems, swelling of face/lips/throat/tongue), flu-like symptoms, swollen or painful joints, increased sensitivity to sunlight, hair loss, abdominal pain, anaemia (may indicate Systemic Lupus Erythematosus).

• [UNSAFE] Celiprolol Hydrochloride may cause side effects which could affect your ability to drive. You may feel dizzy or tired, have problems seeing, shaking or headaches whilst taking it.
• It may cause dizziness. If this happens, get up slowly when rising from a sitting or lying position.
• It can hide symptoms of low blood sugar if you are diabetic. Monitor your blood sugar levels regularly.
• Do not stop taking Celiprolol Hydrochloride suddenly as it can cause your blood pressure to rise suddenly, thereby increasing the risk of heart attack and stroke.
• Consult your doctor if you have liver or kidney problems, Prinzmetal's angina, Raynaud's disease, psoriasis, asthma, thyroid problems, diabetes, or controlled heart failure.

• Hypersensitivity
• Sinus bradycardia
• >1st degree heart block
• Cardiogenic shock
• Uncompensated heart failure
• Hypotensive patients
• Pregnancy (2nd and 3rd trimesters)
• Severe kidney problems
• History of asthma or severe breathing problems
• Untreated phaeochromocytoma
• Metabolic acidosis
• Taking theophylline
• Late stage peripheral arterial occlusive disease or Raynaud's syndrome

May exacerbate rebound HTN upon withdrawal of clonidine. May increase AV conduction time with digitalis glycosides. Reduced bioavailability with concomitant hydrochlorothiazide, chlorthalidone or theophylline. Concomitant dihydropyridine Ca channel blockers (e.g. nifedipine) may increase the risk of hypotension and heart failure.

[UNSAFE] Celiprolol Hydrochloride may cause excessive drowsiness with alcohol.

[CONSULT YOUR DOCTOR] Celiprolol Hydrochloride is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor. Pregnancy Category C. Close monitoring of the neonate is recommended for the first 3 to 5 days of life if taken during pregnancy.

[CONSULT YOUR DOCTOR] Information regarding the use of Celiprolol Hydrochloride during breastfeeding is not available. Please consult your doctor. You should not breast-feed if you are taking Celiprolol Hydrochloride.

Celiprolol Hydrochloride is not recommended for use in children.

Your doctor may decide to lower your dose if necessary.

[CAUTION] Celiprolol Hydrochloride should be used with caution in patients with kidney disease. Dose adjustment of Celiprolol Hydrochloride may be needed. Please consult your doctor. CrCl 15-40: 100-200 mg/day; CrCl <15: Avoid use.

[CAUTION] Celiprolol Hydrochloride should be used with caution in patients with liver disease. Dose adjustment of Celiprolol Hydrochloride may be needed. Please consult your doctor. Low doses are recommended in patients with liver problems.

Overdose symptoms may include: slow heart beats, low blood pressure, feeling dizzy or weak, difficulty in breathing, wheezing or heart problems. Contact your doctor or go to the nearest hospital casualty department immediately.

Keep container in the outer carton. Do not store above 25°C. Do not use this medicine after the expiry date which is stated on the carton.

Celiprolol Hydrochloride