Generic
Cyclosporine Eye prep
5 brands available in the market
At a glance
Cyclosporine Eye prep is an immunosuppressant used for the treatment of keratoconjunctivitis sicca (dry eye disease) and to prevent organ rejection after liver, kidney or heart transplant.
Description
Cyclosporine Eye prep is an immunosuppressant. It works by suppressing your body's immune response to help accept a newly transplanted organ. In keratoconjunctivitis sicca, it acts as an immunomodulator to help regulate tear production. It is also used to treat severe rheumatoid arthritis and psoriasis.
Indications
- Keratoconjunctivitis sicca (dry eye disease)
- Prevention of organ rejection in transplant patients
- Rheumatoid arthritis
- Psoriasis
Therapeutic class
Immunosuppressants
Pharmacological class
Calcineurin Inhibitor / Immunomodulator
Pharmacology
Ciclosporin is a strong immunosuppressant that acts mainly on the helper T-cells. It inhibits the activation of calcineurin and production of interleukin-2, thus reducing cell-mediated immune response. In keratoconjunctivitis sicca, it may act as an immunomodulator to suppress inflammation and help regulate tear production.
Mechanism of action
Cyclosporine inhibits calcineurin activation and interleukin-2 production in helper T-cells, thereby reducing cell-mediated immune response. In keratoconjunctivitis sicca, it acts as an immunomodulator to help regulate tear production.
Dosage
Adult - Keratoconjunctivitis Sicca: 1 drop twice daily approximately 12 hours apart in each eye. May be used with artificial tears; allow 15-minute interval between products.
Child (16 years & above): Keratoconjunctivitis Sicca: 1 drop twice daily approximately 12 hours apart in each eye.
Administration
This medicine is for ophthalmic use only. Take it in the dose and duration as advised by your doctor. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off extra liquid.
Missed dose
If you miss a dose of Cyclosporine Eye prep, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Side effects
Common Side Effects:
- Headache
- Nausea
- Vomiting
- Increased hair growth
- High blood pressure
- Renal dysfunction
- Loss of appetite
- Diarrhea
- Tremor
- Eye irritation or discomfort
- Blurred vision
Precautions & warnings
- Increased risk of infections due to weakened immune system.
- Increased risk of skin cancer; limit exposure to sunlight.
- May affect your ability to drive.
- Regular blood tests are required to monitor blood pressure, liver and kidney function.
- Drink 8-10 glasses of water per day.
- Do not stop taking Cyclosporine Eye prep without talking to your doctor first.
Contraindications
- Active ocular infections
- Hypersensitivity to any of the ingredients in the formulation
Drug interactions
Drugs that increase cyclosporine levels: Diltiazem, doxycycline, erythromycin, ketoconazole, high-dose methylprednisolone, nicardipine, verapamil, oral contraceptives.
Drugs that decrease cyclosporine levels: Carbamazepine, isoniazid, phenobarbitone, phenytoin and rifampicin.
High-dose methylprednisolone: Increased risk of convulsion.
Potentially Fatal: Additive nephrotoxicity with aminoglycosides, amphotericin B, ciprofloxacin, colchicine, melphalan, co-trimoxazole and NSAIDs.
Food interactions
Consuming alcohol with Cyclosporine Eye prep does not cause any harmful side effects.
Use in pregnancy
Cyclosporine Eye prep may be unsafe during pregnancy. Animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it. Please consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Cyclosporine Eye prep is unsafe during breastfeeding. The drug may cause toxicity to the baby.
Pediatric use
Use in children 16 years and above for keratoconjunctivitis sicca is established. Limited information available for other pediatric indications.
Geriatric use
No dosage adjustment is necessary in elderly patients. However, caution should be exercised.
Renal / hepatic impairment
Renal impairment: Use with caution. Dose adjustment may be needed. Please consult your doctor. Regular monitoring of kidney function is advised.
Hepatic impairment: Use with caution. Dose adjustment may be needed. Please consult your doctor. Regular monitoring of liver function is advised.
Overdose effects
No adequate information on overdose is available. Excessive use may lead to local eye irritation or systemic effects. Consult your doctor if symptoms appear.
Storage conditions
Store at 4°C-30°C temperature. Use within 30 days of opening. Keep out of reach of children.
Chemical structure
Cyclosporine