Dicycloverine Hydrochloride

Dicycloverine HCl relieves smooth muscle spasm in the GI and urinary tract. This effect is partly due to antimuscarinic action and partly direct action on the smooth muscle. It works at specific cholinergic (muscarinic) receptors located on the involuntary muscle in the walls of the gut, causing gut muscle relaxation and relieving colic pain.

• Irritable bowel syndrome (IBS)
• Gastrointestinal tract spasm
• Intestinal hypermotility
• Colicky abdominal pain
• Diverticulitis
• Infantile colic

Dicycloverine HCl relieves smooth muscle spasm in the GI and urinary tract. This effect is partly due to antimuscarinic action and partly direct action on the smooth muscle. It binds to cholinergic (muscarinic) receptors on the involuntary muscle in the gut wall, causing muscle relaxation.

Dicycloverine blocks muscarinic receptors and acts directly on smooth muscle to relax intestinal muscles and relieve spasm.

Adult (Oral): 10-20 mg three times daily.
Adult (IM Injection): 20 mg 4 times daily (only for 1-2 days; switch to oral therapy as soon as possible).
Child (2-12 years): 10 mg three times daily.
Child (6 months-2 years): 5-10 mg 3-4 times daily.

May be taken with or without food.

If you miss a dose of Dicycloverine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose. Do not double the dose.

Common: Difficulty in accommodation, exacerbation of glaucoma, tachycardia, palpitations, arrhythmias, urinary retention, restlessness, confusion, excitement, hallucination and delirium.
Potentially Fatal: Respiratory arrest in infants <10 weeks.

Caution in hepatic or renal disease, urinary retention, paralytic ileus, hyperthyroidism, hypertension, congestive heart failure, cardiac tachyarrhythmia, children, elderly, pregnancy.

Intestinal obstruction; intestinal atony; myasthenia gravis; glaucoma; reflux oesophagitis; infants <6 months; lactation.

Metoclopramide: Antagonizes the effect of drugs affecting GI motility.
Antacids: Absorption may be affected.

Can be taken with or without food.

Pregnancy Category B. Should be used during pregnancy only if clearly needed.

It is not known whether Dicycloverine is excreted in breast milk; use with caution.

Contraindicated in infants under 6 months of age.

Use with caution in elderly patients.

Caution in hepatic or renal disease.

Overdose symptoms: headache, nausea, vomiting, blurred vision, dilated pupils, hot dry skin, dizziness, dry mouth, difficulty swallowing, CNS stimulation.

Keep below 30°C temperature, away from light & moisture. Keep out of reach of children.

Dicycloverine Hydrochloride