Generic
Doripenem
8 brands available in the market
At a glance
Doripenem is a carbapenem antibiotic used to treat severe infections of the skin, lungs, stomach, urinary tract, blood and brain (e.g. meningitis). It works by killing bacteria.
Description
Doripenem is a broad-spectrum carbapenem with potent antibacterial activity against aerobic and anaerobic gram-positive and gram-negative bacteria. It inhibits bacterial cell wall synthesis.
Indications
- Severe bacterial infections
Pharmacological class
Carbapenem
Pharmacology
Doripenem is a broad-spectrum carbapenem active against aerobic and anaerobic gram-positive and gram-negative bacteria. It binds to penicillin-binding proteins and inhibits bacterial cell wall synthesis.
Mechanism of action
Doripenem binds to penicillin-binding proteins, inhibiting the final transpeptidase step of peptidoglycan synthesis in bacterial cell walls, leading to bacterial death.
Dosage
Adult Dose:
- Complicated intra-abdominal infections: 500 mg IV every 8 hours for 5-14 days
- Complicated UTI and pyelonephritis: 500 mg IV every 8 hours for 10 days
Renal Dose: CrCl 30-50: 250 mg every 8 hours; CrCl 11-29: 250 mg every 12 hours.
Administration
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Missed dose
If you miss a dose of Doripenem, please consult your doctor.
Drug interactions
Probenecid increases plasma concentration. May decrease valproic acid levels, increasing seizure risk.
Food interactions
Consuming alcohol with Doripenem does not cause any harmful side effects.
Contraindications
- Hypersensitivity
- Anaphylactic reactions to beta-lactams
Side effects
Common Side Effects:
- Vomiting
- Nausea
- Injection site reactions (pain, swelling, redness)
Use in pregnancy
Generally safe during pregnancy. Animal studies show low or no adverse effects.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Use in lactation
Probably safe during breastfeeding. Limited human data suggests no significant risk to the baby.
Precautions & warnings
- Usually given in hospital for serious infections.
- Inform doctor if allergic to penicillin or taking seizure medication.
- Inform doctor if diarrhea, severe abdominal pain or blood in stools.
- Liver and kidney function may be monitored.
Pediatric use
Under 18 years: Safety and efficacy not established.
Geriatric use
Limited information available regarding dose adjustment for elderly patients.
Renal / hepatic impairment
Renal impairment: Use with caution. Dose adjustment may be needed.
Hepatic impairment: Probably safe in liver disease. Dose adjustment may not be needed.
Overdose effects
Limited information on overdose. Overdose is generally not toxic.
Therapeutic class
Other beta-lactam antibiotics
Storage conditions
Store below 25°C, away from light & moisture. Keep out of reach of children.
Chemical structure
Doripenem