Generic
Naftidrofuryl Oxalate
2 brands available in the market
At a glance
Naftidrofuryl Oxalate is used to improve peripheral circulation in peripheral vascular disorders. It works through 5HT2-blocking activity and spasmolytic effects to dilate blood vessels and prevent platelet aggregation.
Description
Naftidrofuryl oxalate possesses 5HT2-blocking activity and counteracts both the vasoconstrictor effect and the effect promoting platelet aggregation due to serotonin. It has a direct effect on intracellular metabolism, increases ATP level, decreases lactic acid level in ischemic conditions and enhances cellular oxidative capacity. It is also a powerful spasmolytic agent.
Indications
- Intermittent claudication
- Cramps in legs at night
- Severe pain in legs while resting (rest pain)
- Pale or blue fingers or toes which get worse when cold
- Raynaud's syndrome or acrocyanosis
- Open sores on legs or feet (trophic ulcers)
- Diabetic arteriopathy
- Gangrene
Therapeutic class
5-HT Agonists
Pharmacological class
Vasodilator
Pharmacology
Naftidrofuryl oxalate possesses 5HT2-blocking activity and counteracts both vasoconstrictor effect and platelet aggregation due to serotonin. It has direct effect on intracellular metabolism, increases ATP level, decreases lactic acid in ischemic conditions and enhances cellular oxidative capacity.
Mechanism of action
Improves peripheral circulation by vasodilation and preventing platelet aggregation.
Dosage
Adult Dose:
- 1-2 capsules three times daily during meals
- Minimum of 3 months or as directed by physician
Administration
- Take with meals
- Take with sufficient amount of water (to prevent esophagitis)
- Do not take without liquid before bedtime
Missed dose
If you miss a dose, take it as soon as you remember; skip if it's almost time for next dose; do not double the dose.
Side effects
Side Effects (Uncommon):
- Diarrhea
- Nausea
- Vomiting
- Epigastric pain
- Skin rash
Rare: Calcium oxalate kidney stones; liver damage
Precautions & warnings
- May promote calcium oxalate kidney stone formation
- May cause liver damage
- Take with sufficient water
Contraindications
- Hypersensitivity
- History of hyperoxaluria or recurrent calcium-containing kidney stones
Drug interactions
No known interactions.
Food interactions
Take with food for better absorption.
Use in pregnancy
Use in Pregnancy: Not advisable during pregnancy due to lack of relevant clinical data.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Should not be used by breastfeeding women due to lack of specific data on excretion in human milk.
Pediatric use
Safety and efficacy not established in children.
Geriatric use
Elderly may require dose adjustment.
Renal / hepatic impairment
Renal Impairment: Caution in kidney disease; dose adjustment may be needed.
Hepatic Impairment: Cases of liver damage reported; caution in liver disease.
Overdose effects
Overdose: Depression of cardiac conduction and convulsions may occur; symptomatic treatment.
Storage conditions
Store below 25°C; protect from light & moisture; keep out of reach of children.
Chemical structure
Naftidrofuryl Oxalate