Generic
Sodium Fusidate (Fusidic Acid)
3 brands available in the market
At a glance
Sodium Fusidate (Fusidic Acid) is an antibiotic used for the treatment of bacterial skin infections. It inhibits bacterial protein synthesis to prevent the spread of infection.
Description
Sodium Fusidate binds to the 50S ribosomal subunit of bacteria, inhibiting the translocation process, preventing peptide chain elongation and halting protein synthesis. It is primarily active against Gram-positive bacteria, especially Staphylococcus aureus.
Indications
- Bacterial skin infections
Therapeutic class
Topical Antibiotic
Pharmacological class
Peptide Translocase Inhibitor
Pharmacology
Sodium Fusidate binds to the 50S subunit of the bacterial ribosome, inhibiting the translocation step of protein synthesis. This prevents peptide chain elongation in susceptible bacteria, stopping bacterial growth and spread.
Mechanism of action
Suppresses infection by inhibiting bacterial protein synthesis.
Dosage
Adult Dose (Oral):
- Susceptible infections: 500 mg three times daily
- Severe infections: Up to 1 g three times daily
Pediatric Dose (Oral):
- <1 year: Approximately 15 mg/kg
- 1-5 years: 250 mg
- 5-12 years: 500 mg
- Doses to be taken three times daily
Administration
- Topical: Clean and dry the affected area; gently massage the ointment
- Oral: Take with food as prescribed by your doctor
- Oral tablets: Swallow whole; do not chew
Missed dose
If you miss a dose, take it as soon as you remember; if almost time for the next dose, skip it; do not double the dose.
Side effects
Common Side Effects:
- Application site burning, irritation, itching, and redness
- Nausea, abdominal pain (oral)
Precautions & warnings
- For external use only (topical)
- Avoid contact with eyes, nose, or mouth
- Do not use more often or for longer than advised
- Caution in pregnancy and lactation
Contraindications
- Hypersensitivity to sodium fusidate or any component
Drug interactions
- Antistaphylococcal penicillin: Synergistic action
- Ciprofloxacin: Antagonistic effect
Food interactions
Caution is advised when consuming alcohol with Sodium Fusidate; consult your doctor.
Use in pregnancy
Use in Pregnancy: Generally safe; animal studies show low or no adverse effects; limited human data; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Safe during breastfeeding; limited data suggests no significant risk; consult your doctor.
Pediatric use
Indicated for children (weight-based dosing)
Geriatric use
Caution required in elderly patients
Renal / hepatic impairment
Renal Impairment: Safe in kidney disease; dose adjustment may not be needed; consult your doctor.
Hepatic Impairment: Caution required; dose adjustment may be needed; consult your doctor.
Overdose effects
No overdose information available; excessive doses may increase side effects; consult your doctor.
Storage conditions
Store in a cool and dry place, protected from light; keep out of reach of children.
Chemical structure
Sodium Fusidate