Generic
Tulobuterol Hydrochloride
4 brands available in the market
At a glance
Tulobuterol Hydrochloride is used for the treatment of asthma and chronic obstructive pulmonary disorder (COPD). It helps in relaxing the muscles of the air passages, thus widening it and making it easier to breathe.
Description
Tulobuterol is a direct-acting sympathomimetic with selective action on β2-receptors. It is available orally, as an inhaler and as a transdermal patch. It is given as the hydrochloride by mouth and the base as transdermal formulation and inhalation.
Indications
- Asthma
- Chronic obstructive pulmonary disease (COPD)
- Bronchial asthma
- Chronic bronchitis
- Asthmatic bronchitis
- Pulmonary emphysema
- Bronchiectasis
Therapeutic class
Short-acting selective & β2-adrenoceptor stimulants
Pharmacological class
β2-Adrenergic Agonist
Pharmacology
Tulobuterol is a direct-acting sympathomimetic with selective action on β2-receptors. The primary pharmacological action of beta-adrenergic drugs is to stimulate adenyl cyclase, the enzyme which catalyzes the formation of cyclic AMP from ATP. The cyclic AMP thus formed mediates the cellular response that results in bronchodilation.
Mechanism of action
Stimulates β2-receptors, relaxing bronchial smooth muscle and widening airways.
Dosage
Adult Dose (Oral):
- Bronchodilation: Initially 1-2 mg twice daily; increase to 2 mg three times daily if necessary
- Tablets: Start 1 mg twice daily; may increase to 2 mg twice daily after 7-10 days; may increase to 6 mg/day if necessary
Child Dose (Oral):
- 1-6 years: 0.25-0.5 mg twice daily
- 6-10 years: 0.5-1 mg twice daily
- 10-14 years: 1-1.5 mg twice daily
- Syrup: 40-80 mcg/kg/day in two divided doses
Administration
- Make sure skin is clean and dry
- Remove protective liner of the patch; do not touch sticky side
- With sticky side down, place patch evenly onto skin
- Do not wear more than one patch at a time
- Use one new patch each day, changing the place to avoid skin irritation
Missed dose
If you miss a dose, skip it and continue with your normal schedule; do not double the dose.
Side effects
Common Side Effects:
- Tremor
- Headache
- Restlessness
- Insomnia
- Palpitations
- Muscle cramp
- Hypertension
- Angina
- Tachycardia
- Vomiting
- Vertigo
- CNS stimulation
Precautions & warnings
- Unknown if alters ability to drive; caution advised
- Use long-term only in patients whose asthma cannot be adequately controlled on controller medications alone
- Use with caution in diabetes mellitus, hypertension, hyperthyroidism, and seizure disorders
- Caution in renal failure; kidney is principal route of elimination
- Dosage may require individualization in impaired liver function
- Administer cautiously to cardiac patients, especially those with arrhythmias, coronary insufficiency, or myocardial ischemia
Contraindications
- Phaeochromocytoma
- Hypersensitivity to sympathomimetic amines or any formulation components
Drug interactions
- Digoxin: increased risk of arrhythmia
- Xanthines, corticosteroids, and diuretics: hypokalaemia
Food interactions
No food interactions known.
Use in pregnancy
Use in Pregnancy: Information not available; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Information not available; consult your doctor.
Pediatric use
Pediatric dosage regimen established (1-14 years)
Geriatric use
Initial dose may be lower in elderly, particularly with history of sensitivity to beta-adrenergic agents
Renal / hepatic impairment
Renal Impairment: Limited information; caution in renal failure
Hepatic Impairment: Limited information; dosage individualization may be needed
Overdose effects
Symptoms: Tremor, tachycardia, palpitations, hypotension.
Treatment: Supportive care.
Storage conditions
Store in a dry place, away from light and moisture; keep out of reach of children.