Audicare
0.3%+1%+0.025%+2%Rx৳ 150/unit
Pack: ৳ 150
৳ 150/unit
Pack: ৳ 150
At a glance
Ofloxacin + Clotrimazole + Beclomethasone + Lidocaine is a combination ear drop used for superficial bacterial and fungal infections of the external auditory canal and middle ear. It contains antibacterial, antifungal, anti-inflammatory and local anesthetic components.
Indications
- Superficial bacterial and fungal infections of the external auditory canal and middle ear
Pharmacology
Ofloxacin inhibits DNA gyrase to prevent bacterial DNA replication. Clotrimazole inhibits cytochrome P-450-mediated ergosterol synthesis to reduce fungal cell wall integrity. Beclomethasone induces phospholipase A2 to inhibit prostaglandin and leukotriene release. Lidocaine blocks sodium channels to provide local anesthesia.
Dosage
Adult and Pediatric Dose (Ear Drops):
- 2-5 drops 3-4 times daily for 7-14 days
- Otitis externa (intact tympanic membrane): 6 months+
- Chronic suppurative otitis media (perforated tympanic membrane): 12 years+
Side effects
Side Effects:
- Itching
- Burning
- Irritation
- Dryness
- Earache
- Headache
- Vertigo
- Dizziness
- Redness
- Folliculitis
- Hypertrichosis
- Hypopigmentation
Use in pregnancy
Use in Pregnancy: Safety not established; weigh benefit against potential risk to fetus.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Discontinue and obtain cultures if no response in 1 week
- Prolonged use may result in overgrowth of nonsusceptible organisms
- Discontinue if local irritation or sensitization occurs
- If otorrhea persists or recurs, evaluate for cholesteatoma, foreign body, or tumor
- Not for ophthalmic use
- Not for injection
Overdose effects
Overdose unlikely (topical use); symptomatic treatment.
Storage conditions
Store away from light and moisture, below 25°C; keep out of reach of children.