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At a glance

Monosulfiram is an ectoparasiticide used for the treatment and prevention of scabies. It is active against the burrowing mite Sarcoptes scabiei.

Indications
  • Treatment of scabies (Sarcoptes scabiei)
  • Prophylaxis of scabies
Pharmacology

Monosulfiram is an ectoparasiticide active against the scabies mite (Sarcoptes scabiei). It acts on the mite's nervous system to inactivate them.

Dosage

Adult Dose (Topical):

  • 25% solution: Dilute with 2-3 parts water before application
  • Apply diluted solution to entire body (except face and scalp)
  • Allow 10 minutes to dry, then dress
  • In difficult cases, repeat for 2-3 days

Prophylaxis: Use daily for as long as infection risk remains

Side effects

Side Effects:

  • Erythematous rash (rare)
  • Idiosyncratic reactions
Use in pregnancy

Use in Pregnancy: Pregnancy Category not classified; FDA has not yet classified into a specified category. Consult your doctor.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Do not apply near naked flame (solution is flammable)
  • Due to chemical relationship with disulfiram, avoid alcohol before and for at least 48 hours after application
  • Avoid contact with eyes and mucous membranes
Overdose effects

Overdose (ingestion): Flushing, dyspnea, headache, dizziness, nausea, vomiting, drowsiness; tachycardia and hypotension may occur; symptomatic treatment (oxygen, cardiac stimulants, IV sodium thiosulfate)

Storage conditions

Store below 35°C (room temperature); do not store in cold place (crystals may deposit); flammable, keep away from naked flame.

Monosulfiram — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.