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At a glance

Bacitracin Zinc + Neomycin Sulphate + Polymixin B topical is a combination antibiotic used for the treatment of bacterial skin infections. It is effective against both gram-positive and gram-negative bacteria.

Indications
  • Bacterial skin infections (impetigo, boils, infected wounds)
  • Post-surgical infection prevention
Pharmacology

Neomycin is an aminoglycoside antibiotic that binds to the 30S subunit of the bacterial ribosome, inhibiting protein synthesis and disrupting DNA synthesis. It is active against gram-negative aerobes and some strains of staphylococci.

Bacitracin inhibits bacterial cell wall peptidoglycan synthesis and is active against gram-positive bacteria (staphylococci, streptococci, corynebacteria, clostridia) and some gram-negative species (Neisseria and Haemophilus influenzae).

Polymyxin B binds to membrane phospholipids, disrupting the bacterial cytoplasmic membrane of most gram-negative organisms, allowing leakage of intracellular constituents.

Dosage

Adults and Children: Apply topically to affected area 3 times daily.

Side effects
  • Application site burning
  • Itching
  • Redness
  • Scaling

In most cases, these reactions are mild and temporary.

Use in pregnancy

[CONSULT YOUR DOCTOR] Limited safety data during pregnancy (Category C). Animal studies have shown harmful effects on the developing baby. Use only if clearly needed and under medical supervision.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Apply only to affected areas
  • Do not apply to broken or damaged skin
  • Avoid contact with eyes, nose, or mouth
  • Do not use airtight dressings or bandages unless directed by a doctor
  • Prolonged use may cause overgrowth of non-susceptible organisms, including fungi
  • Caution during pregnancy and lactation
Overdose effects

Overuse may cause systemic absorption and toxicity. Consult a doctor if symptoms occur.

Storage conditions

Store in a cool and dry place, protected from light. Keep out of reach of children.

Bacitracin Zinc + Neomycin Sulphate + Polymixin B topical — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.