Topiclo-S

• Psoriasis
• Chronic atopic dermatitis
• Neurodermatitis (lichen simplex chronicus)
• Lichen planus
• Eczema (nummular eczema, hand eczema, eczematous dermatitis)
• Seborrheic dermatitis of the scalp
• Ichthyosis vulgaris and other ichthyotic conditions

Clobetasol Propionate is a high potency corticosteroid. Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; and reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation. Salicylic acid has a potent keratolytic action which softens and destroys the stratum corneum by increasing endogenous hydration which causes the horny layer of the skin to swell, soften, and then desquamate.

Adult Dose (Topical): Apply a thin layer to the affected skin areas twice daily and rub in gently & completely. Therapy should be discontinued when control has been achieved. If no improvement is seen within 2 weeks, reassessment of diagnosis may be necessary. Should not be used with occlusive dressing. Treatment beyond 2 consecutive weeks and exceeding 50 gm/week is not recommended.

Pediatric Dose (under 12 years): Not recommended.

Common Side Effects:

• Skin peeling
• Thinning of skin
• Application site reactions (burning, stinging, itching and redness)
• Dryness

Serious Side Effects (long-term/large area use): Hypercortisolism (adrenal suppression), local atrophy, systemic absorption, salicylate toxicity (tinnitus, dizziness, deafness).

[CONSULT YOUR DOCTOR] Clobetasol Propionate + Salicylic Acid topical may be unsafe to use during pregnancy. Topical administration of corticosteroids to pregnant animals can cause abnormalities of fetal development. Pregnancy Category C.

• Use with caution on lesions close to the eye.
• Prolonged use over extensive areas may lead to adrenal suppression; pediatric patients are more susceptible.
• Appropriate antimicrobial therapy should be used when treating inflammatory lesions that have become infected.
• Should not be used with occlusive dressing.
• Avoid contact with broken or inflamed skin.
• Caution during pregnancy and lactation.

Acute overdosage is very unlikely to occur. In the case of chronic overdosage or misuse, features of hypercortisolism may appear. Symptoms of systemic salicylate poisoning (tinnitus, dizziness, deafness) have been reported after application to large areas of skin and for prolonged periods.

Store in a cool and dry place, protected from light. Keep out of reach of children.