৳ 215.61/unit
Pack: ৳ 215.61
৳ 215.61/unit
Pack: ৳ 215.61
At a glance
Mesna Disulfide is used to prevent ifosfamide-induced hemorrhagic cystitis. It reduces the risk of bladder inflammation and bleeding in patients receiving ifosfamide.
Indications
- Prophylaxis of ifosfamide-induced hemorrhagic cystitis
- Prevention of urothelial toxicity associated with ifosfamide or cyclophosphamide
Pharmacology
Mesna Disulfide detoxifies ifosfamide's urotoxic metabolites (acrolein) by reacting with thiol groups in the renal tubule, reducing the risk of bladder inflammation and bleeding.
Dosage
Adult Dose (IV):
- 240 mg/sq.meter IVP with ifosfamide dose, 15 minutes before and 4 and 8 hours after ifosfamide administration
- Adjust dose if ifosfamide dose changes
Side effects
Common Side Effects:
- Nausea
- Headache
- Lightheadedness
- Lethargy
- Abdominal pain
- Flushing
- Diarrhea
- Rash
- Fever
- Flu-like symptoms
Use in pregnancy
Use in Pregnancy: Mesna Disulfide is generally considered safe during pregnancy; animal studies have shown low or no adverse effects to the developing baby.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Drink at least 1 litre of fluid daily
- Seek immediate medical attention for severe allergic reactions (rash, itching, breathing difficulty, swelling of mouth/face/lips/tongue)
- Caution when driving or operating machinery (may cause drowsiness, dizziness, blurred vision)
- Will be monitored for blood or protein in urine during treatment
Overdose effects
No specific overdose information available; symptomatic and supportive treatment.
Storage conditions
Store in a cool and dry place; keep out of reach of children.