Bendamustine

Bendamustine is used to treat cancer of the lymphatic system such as Non-Hodgkin's Lymphoma (NHL). It may also be used to treat other types of cancer as determined by your doctor. It can be used alone, or together with certain other medicines as part of combination chemotherapy. Bendamustine is given as an injection into vein under the supervision of a doctor and should not be self-administered. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include anemia (low number of red blood cells), decreased white blood cell count, infection, fatigue, nausea, and vomiting. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Inform your doctor if you have a medical history, of bleeding disorders, heart or liver disease, radiation treatment or any infection. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is known to reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. Bendamustine is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

• Non-Hodgkin's lymphoma • Blood cancer • Multiple myeloma

Bendamustine is an antineoplastic alkylating agent. It interferes w/ DNA replication and RNA transcription that leads to disruption of nucleic acid function. It is also active against inert and dividing cells.

Adult Dose: Intravenous Chronic lymphocytic leukaemia Adult: 100 mg/m2 infused over 30-60 min on days 1 and 2 of a 28-day cycle for up to 6 cycles. For severe haematological or non-haematological toxicity: Reduce dose to 50 mg/m2 on days 1 and 2 of each cycle. If severe haematological toxicity recurs, further reduce dose to 25 mg/m2 on days 1 and 2 of each cycle. May consider dose re-escalation in subsequent cycles. Multiple myeloma Adult: 120-150 mg/m2 infused over 30-60 min on days 1 and 2 of a 28-day cycle. IV or oral prednisone may be given at a dose of 60 mg/m2 on days 1-4 of the cycle. Non-Hodgkin's lymphoma Adult: 120 mg/m2 infused over 30-60 min on days 1 and 2 of a 21-day cycle for up to 8 cycles. For severe haematological or non-haematological toxicity: Reduced to 90 mg/m2 on days 1 and 2 of each cycle. If severe toxicity recurs, further reduce dose to 60 mg/m2 on days 1 and 2 of each cycle. Hepatic Impairment Mild: Use caution Moderate: Reduce dose by 30%. Severe hepatic impairment: Use not recommended Renal Dose: Renal Impairment Mild-to-moderate: Use caution CrCl <40 mL/min: Not recommended

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Bendamustine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Anemia (low number of red blood cells) • Decreased white blood cell count • Infection • Fatigue • Nausea • Fever • Vomiting • Low blood platelets • Mucosal inflammation

[CONSULT YOUR DOCTOR] It is not known whether Bendamustine alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Bendamustine is given as an injection into vein under the supervision of a doctor.

Patient w/ history of hypersensitivity (e.g. anaphylaxis and anaphylactoid reactions); jaundice, severe bone marrow suppression, low leukocyte or platelet count. Severe hepatic impairment. Major surgery <30 days prior to treatment.

May increase plasma levels w/ CYP1A2 inhibitors (e.g. ciprofloxacin, fluvoxamine). May reduce plasma levels w/ CYP1A2 inducers (e.g. omeprazole and tobacco smoking).

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Bendamustine. Please consult your doctor.

[CONSULT YOUR DOCTOR] Bendamustine is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[UNSAFE] Bendamustine is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

[SAFE IF PRESCRIBED] Bendamustine is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Bendamustine may not be needed in these patients. Please consult your doctor. [CAUTION] Bendamustine should be used with caution in patients with liver disease. Dose adjustment of Bendamustine may be needed. Please consult your doctor.

Symptoms of lymphoma And blood cancer Symptoms could be like fever, weight loss, anorexia, lymphadenopathy. Please tell me the interpretation of the attach report, if possible. Also guide for further treatment process. U r having multiple myeloma I have non hodgking&#x27;s lymphoma. What type of treament i need? And it this cancer curable? If CD 20+ TAKE R-CHOP TREATMENT Multiple myeloma can be cured or not Yes, if diagnosed at the right stage Non Hodgkin lymphoma of defuss large b cells I am very much experienced in treating DLBCL Loose motions in cancer pateint Hi my mother has been diagnosed with lymphoma hodgkin&#x27;s (stage 1A) and now when ever she is eats she has to run to washroom for watery stools can u please suggest any ayurvedic medicine which is safe to take Take bilbadi churan 1 spoon twice with water, Report shows higher esr value what should i do. A very high ESR usually has an obvious cause, such as a severe infection, marked by an increase in globulins, polymyalgia rheumatica or temporal arteritis. A health practitioner will typically use other follow-up tests, such as blood cultures, depending on the person&#x27;s symptoms. People with multiple myeloma or Waldenstrom&#x27;s macroglobulinemia (tumors that make large amounts of immunoglobulins) typically have very high ESRs even if they don&#x27;t have inflammationNeed to correlate clinicallyKindly consult your doctor Can we take homeopathic and ayurveda medicines together to cure lymphoma hockings cancer No. You can one pathy as supportive treatment with allopathy treatment.