Generic
Benzocaine + Oxytetracycline + Polymyxin B Eye prep
1 brands available in the market
At a glance
Benzocaine + Oxytetracycline + Polymyxin B Eye prep is a combination ophthalmic preparation used for the treatment of bacterial eye infections and corneal inflammation.
Description
Benzocaine + Oxytetracycline + Polymyxin B is a combination eye preparation containing three active ingredients that work synergistically. Benzocaine is a local anesthetic that prevents the generation and transmission of impulses along nerve fibers. Oxytetracycline is a broad-spectrum antibiotic that binds to the 30S ribosomal subunit, inhibiting bacterial protein synthesis. Polymyxin B disrupts the bacterial cytoplasmic membrane of most gram-negative organisms.
Eye drops: 1-2 drops 2-4 times daily.
Indications
- Bacterial eye infections
- Inflammation of the Cornea
Therapeutic class
Ophthalmic Antibiotic Combination
Pharmacological class
Local Anesthetic + Antibiotic + Polymyxin
Pharmacology
Benzocaine is a local anesthetic that prevents the generation and transmission of impulses along nerve fibers and at nerve endings. Depolarization and ion-exchange are inhibited. In general, loss of pain occurs before loss of sensory, autonomic and motor functions.
Oxytetracycline binds reversibly to the 30S and possibly 50S ribosomal subunits, inhibiting bacterial protein synthesis and arresting cell growth. It is active against a wide range of gram-positive and gram-negative organisms.
Polymyxin B disrupts the bacterial cytoplasmic membrane of mostly gram-negative organisms by binding to membrane phospholipids, allowing leakage of intracellular constituents.
Mechanism of action
Benzocaine blocks sodium channels in nerve cells, reducing pain sensation. Oxytetracycline inhibits bacterial protein synthesis, stopping bacterial growth. Polymyxin B disrupts the cell membrane of gram-negative bacteria. Together, they provide effective treatment against infections.
Dosage
Eye Drops: 1-2 drops 2-4 times daily.
Administration
For ophthalmic use only. Shake well before use. Do not touch the dropper tip to the eye or any surface. Keep eyes closed for 1-2 minutes after application. If using other eye drops, maintain 5-10 minutes gap.
Missed dose
If you miss a dose, apply as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Side effects
- Local sensitivity
- Lid itching
- Swelling
- Conjunctival erythema
Rare: Allergic reactions
Precautions & warnings
- Prolonged use may cause overgrowth of non-susceptible organisms
- Avoid use with perforated eardrum
- Avoid if allergic to any component
- Consult doctor before use if wearing contact lenses
Contraindications
- Hypersensitivity to benzocaine, oxytetracycline, polymyxin B, or any component
Drug interactions
No significant drug interactions are known. Consult your doctor before using with other eye drops.
Food interactions
No food-related restrictions (eye drops).
Use in pregnancy
[CONSULT YOUR DOCTOR] Limited safety data during pregnancy. Use only if clearly needed and under medical supervision.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
[CONSULT YOUR DOCTOR] Excretion in breast milk is unknown. Use with caution in nursing mothers.
Pediatric use
Pediatric dosage is same as adults (1-2 drops 2-4 times daily). Consult doctor before use in neonatal eye infections.
Geriatric use
No dose adjustment needed for elderly patients.
Renal / hepatic impairment
Systemic absorption with topical ophthalmic application is minimal, but caution is advised in severe renal or hepatic impairment.
Overdose effects
Overuse may cause local irritation or allergic reactions. Consult a doctor if symptoms occur.
Storage conditions
Store in a cool and dry place, protected from light. Keep out of reach of children.
Chemical structure
Benzocaine + Oxytetracycline + Polymyxin B