Cholestyramine

Cholestyramine is used to lower cholesterol and to reduce the risk of heart disease. Cholesterol is a fatty substance that builds up in your blood vessels and causes narrowing, which may lead to a heart attack or stroke. Cholestyramine may also be used to treat itching seen in certain types of liver disease and to relieve some types of diarrhea. This medicine may be used alone or in combination with other medicines. It may be taken with a meal or on an empty stomach. You can take it at any time of day but try to take it at the same time each day. Most people with high cholesterol do not feel ill, but if you stop taking this medicine, your condition could get worse. This may lead to your cholesterol levels creeping up again and increase your risk of heart disease and stroke. It is important to have your cholesterol levels checked regularly. This medicine is only one part of a treatment program which should also include a healthy diet, regular exercise, smoking cessation, moderation of alcohol intake and weight reduction. You can eat normally while taking this medicine, but try to avoid foods that are high in fat. Common side effects of this medicine include constipation and gas. These are usually mild and disappear after a short time. Before taking it, let your doctor know if you are suffering from any liver or kidney disease. Pregnant and breastfeeding women should consult the doctor before taking this medicine. Cholestyramine is a bile acid binding agent. It removes bile acids from the body. The liver then produce more bile acids using cholesterol, as a result, the levels of cholesterol in the body is lowered.

• High cholesterol

Colestyramine binds with bile acids to form an insoluble complex which is excreted in the feces, resulting in increased loss of bile acid, thus increasing the oxidation of cholesterol to bile acids.

Adult Dose: Hyperlipidaemias Adult: 12-24 g daily in single dose or up to 4 divided doses. Bile acid-induced diarrhoea Adult: 12-24 g daily in single dose or up to 4 divided doses. Pruritus associated with partial biliary obstruction or primary biliary cirrhosis Adult: 4-8 g daily. Child Dose: Hyperlipidaemias Child: >6 yr: 240 mg/kg daily in divided doses. Bile acid-induced diarrhoea Child: >6 yr: 240 mg/kg daily in divided doses. Pruritus associated with partial biliary obstruction or primary biliary cirrhosis Child: >6 yr: 240 mg/kg daily in divided doses.

Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Empty the granules in a glass of water/milk, stir it and consume immediately. Cholestyramine may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Cholestyramine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Constipation

[SAFE] Cholestyramine does not usually affect your ability to drive. Always take it with food and a full glass of water. It may interfere with the absorption of vitamins such as A, D and K. Take supplements of these vitamins as suggested by your doctor. It can delay or decrease the absorption of certain medicines. Any other medicine should be taken 1 hour before or 4 hours after taking Choltran Powder for Oral Suspension.

Complete biliary obstruction; hypersensitivity.

Delayed or reduced absorption of folic acid, thiazide diuretics, propranolol, digoxin and related glycosides, loperamide, phenylbutazone, barbiturates, oestrogens, progestogens, thyroid hormones, warfarin and other coumarin-derivative anticoagulants, iron salts, deferasirox and some antibacterials (e.g. tetracycline, penicillin G). May prevent absorption of fat-soluble vit. Slightly decreased rate of absorption of clofibrate. May interfere w/ absorption of oral phosphate supplements.

[CAUTION] Caution is advised when consuming alcohol with Cholestyramine. Please consult your doctor.

[CONSULT YOUR DOCTOR] Cholestyramine may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Cholestyramine is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[SAFE IF PRESCRIBED] Cholestyramine is safe to use in patients with kidney disease. No dose adjustment of Cholestyramine is recommended. However, talk to your doctor if you have any underlying kidney disease as the information available is very limited. [CONSULT YOUR DOCTOR] There is limited information available on the use of Cholestyramine in patients with liver disease. Please consult your doctor.

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