Flucloxacillin

Flucloxacillin is an antibiotic used to treat a variety of bacterial infections. It is effective in infections of the throat, ear, nasal sinuses, respiratory tract, skin and soft tissue, bones and joints and blood. Flucloxacillin is a penicillin-type of antibiotic, which mainly fights and stops the growth of the gram-positive type of bacteria. It is given as a drip (intravenous infusion) or as an injection directly into a vein or a muscle under the supervision of a healthcare professional. This medicine should be used regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping the medicine too early may lead to the infection returning or worsening. The total duration of treatment and precise dosage will be decided by your doctor, depending on the type of infection that you have and how well you respond to the medication. Before taking this medicine, inform your doctor if you are allergic to penicillin or penicillin-type of medicine. Nausea, vomiting, diarrhea and local pain, swelling, redness at the site of injection may be seen as side effects in some patients. These are temporary and usually resolve quickly. Consult your doctor if any of these side effects persist or if your condition worsens. This medicine is generally regarded as safe to use during pregnancy if used under a doctor's supervision. Flucloxacillin is an antibiotic. It kills bacteria by preventing them from forming their own protective covering (cell wall) which is needed for them to survive.

• Bacterial infections

Flucloxacillin inhibits the 3rd and last step of bacterial cell wall synthesis by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall. It is active against penicillinase-producing and non-penicillinase-producing staphylococci.

Adult Dose: Adults (including elderly patients): Oral: 250-500mg 3-4 times a day. Intravenous IV 0.25-1 g 4 times/day, may double in severe cases. Up to 8 g/day in 3-4 divided doses may be given for osteomyelitis. Up to 8 g/day in 4 divided doses for endocarditis in patients weighing 85 kg. Child Dose: Children have been given doses of 12.5-25 mg/kg body weight 4 times a day. Intravenous 2-10 years: Half of adult dose Under 2 years: One fourth of adult dose Renal Dose: Renal impairment: CrCl (ml/min) <10 Dosage adjustment may be necessary.

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it.

If you miss a dose of Flucloxacillin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Nausea • Vomiting • Diarrhea • Allergic reaction • Injection site reactions (pain, swelling, redness)

[SAFE] Flucloxacillin does not usually affect your ability to drive. You have been prescribed Flucloxacillin for the treatment of bacterial infections. It is given by an injection into a vein or muscle, or via a drip into a vein. Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat. Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools. Inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking this medicine.

Hypersensitivity to penicillins. Porphyria.

May increase the risk of methotrexate toxicity. May decrease the efficacy of oestrogen-containing OC. Enhanced plasma concentrations w/ probenecid. Bacteriostatic drugs (e.g. chloramphenicol, tetracycline) may interfere w/ the bactericidal effect of flucloxacillin. May prolong bleeding time in patients on oral anticoagulants.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Flucloxacillin. Please consult your doctor.

[SAFE IF PRESCRIBED] Flucloxacillin is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[CAUTION] Flucloxacillin should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.

There is no data available. Please consult doctor before consuming the drug. There is no data available. Please consult doctor before consuming the drug.

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