Generic
Imeglimin Hydrochloride
7 brands available in the market
At a glance
Imeglimin Hydrochloride is used for the treatment of Type 2 Diabetes Mellitus as a monotherapy adjunct to diet and exercise.
Description
Imeglimin Hydrochloride is an oral antidiabetic medication used for the treatment of Type 2 Diabetes Mellitus. It amplifies glucose-stimulated insulin secretion (GSIS) and preserves β-cell mass. It also enhances insulin action by inhibiting hepatic glucose output and improving insulin signaling in both liver and skeletal muscle. At a cellular and molecular level, Imeglimin corrects mitochondrial dysfunction, a common underlying element of T2D pathogenesis.
Indications
- Type 2 Diabetes Mellitus (as monotherapy adjunct to diet and exercise)
Therapeutic class
Antidiabetic Drug
Pharmacological class
Mitochondrial Modulator/Insulin Sensitizer
Pharmacology
Imeglimin's mechanism involves dual effects: (a) amplification of glucose-stimulated insulin secretion (GSIS) and preservation of β-cell mass; and (b) enhanced insulin action, including inhibition of hepatic glucose output and improvement in insulin signalling in liver and skeletal muscle. At a cellular level, it corrects mitochondrial dysfunction, rebalances respiratory chain activity (partial inhibition of Complex I and correction of Complex III activity), reduces reactive oxygen species formation, and prevents mitochondrial permeability transition pore opening.
Mechanism of action
Controls blood sugar by amplifying glucose-stimulated insulin secretion, preserving β-cell mass, inhibiting hepatic glucose output, and correcting mitochondrial dysfunction.
Dosage
Adult Dose (Oral):
- Usual dosage: 1000 mg (2 tablets) twice daily (morning and evening)
- Take with food
Renal Dose: Safe in kidney disease; no dose adjustment recommended
Child Dose: Not recommended
Administration
Take with food; swallow whole tablet; do not chew, crush or break; follow the dose and duration as advised by your doctor.
Missed dose
If you miss a dose, take it as soon as possible; if it is almost time for your next dose, skip the missed dose and go back to regular schedule; do not double the dose.
Side effects
Most Common:
- Nausea
- Diarrhea
- Constipation
- Hypoglycemia (low blood glucose)
- Weakness
- Hungry feeling
- Sweating
Precautions & warnings
Precautions:
- It is not known whether Imeglimin alters the ability to drive
- Hypoglycemic symptoms may occur; be cautious when working at heights, driving, or operating dangerous machinery
- If hypoglycemia occurs, take sugar-containing foods or sugar (if taking alpha-glucosidase inhibitor, take glucose)
- Dose reduction may be required for patients with renal impairment (eGFR <15 mL/min/1.73 m2)
Contraindications
Contraindications:
- Hypersensitivity
- Severe ketosis, diabetic coma or pre-coma
- Type 1 diabetes (for emergency hyperglycemia)
- Renal failure, severe renal or hepatic impairment
- Cardiac failure, CHF, IDDM
- Pregnancy, lactation
Drug interactions
Drug Interactions:
- Thiazide diuretics, corticosteroids, phenothiazines, OC, sympathomimetics, niacin, Ca channel blockers, isoniazid may exacerbate loss of glycemic control
- ACE inhibitors may reduce fasting blood glucose
- May increase serum level with cimetidine
- Iodinated contrast agents may increase risk of metformin-induced lactic acidosis
Food interactions
Food Interactions: It is unsafe to consume alcohol with Imeglimin Hydrochloride.
Use in pregnancy
Use in Pregnancy: Not enough reliable information; should be used in pregnant women only if expected therapeutic benefits outweigh possible risks.
Use in lactation
Use in Lactation: Not enough reliable information; transfer to milk reported in animal studies; breastfeeding must be discontinued.
Pediatric use
Not recommended for children.
Geriatric use
No specific data for elderly.
Renal / hepatic impairment
Renal Impairment: Caution in kidney disease; dose adjustment may be needed; dose reduction may be required for eGFR <15 mL/min/1.73 m2; not recommended in severe kidney disease.
Hepatic Impairment: Caution in liver disease; dose adjustment may be needed; start with low dose in mild to moderate liver disease; not recommended in severe liver disease.
Overdose effects
Overdose: Remove unabsorbed material from GI tract; clinical monitoring (including ECG); institute supportive therapy if required.
Storage conditions
Store below 30°C temperature and dry place, protected from light; keep out of reach of children.
Chemical structure
Imeglimin Hydrochloride