Generic
Potassium Chloride 0.1% + Sodium Acetate 0.65% + Sodium Chloride 0.5%
12 brands available in the market
At a glance
Potassium Chloride 0.1% + Sodium Acetate 0.65% + Sodium Chloride 0.5% is used for the treatment of diarrhea, dehydration, cholera, vomiting, and fluid and electrolyte loss.
Description
Sodium plays an important role in controlling total body water and its distribution. Sodium Chloride is the major extracellular cation important for electrolyte and fluid balance. Sodium Acetate provides an alternate source of bicarbonate through metabolic conversion in the liver. Potassium Chloride is a major cation of intracellular fluid, playing a role in nerve conduction and muscle contraction.
Indications
- Diarrhea
- Dehydration
- Cholera
- Vomiting
- Fluid and electrolyte loss
Therapeutic class
Electrolyte & Fluid Replacement Solution
Pharmacological class
Intravenous Electrolyte Solution
Pharmacology
Sodium Chloride is important for electrolyte and fluid balance, osmotic pressure control, and water distribution. Sodium Acetate provides a bicarbonate source through hepatic metabolic conversion, helping to prevent acidosis. Potassium Chloride is a major intracellular cation involved in nerve conduction, muscle contraction, and acid-base balance.
Mechanism of action
Restores electrolyte balance and prevents acidosis.
Dosage
Adult Dose (IV):
- As required; depends on patient's age, weight, and clinical condition
- Recommended flow rate: up to 100 drops/minute/70 kg body weight
Administration
- Administered by healthcare professional as IV infusion only
- Do not administer rapidly or for prolonged periods
Missed dose
If you miss a dose, consult your doctor.
Side effects
Side Effects:
- Febrile response
- Infection at injection site
- Venous thrombosis or phlebitis
- Extravasation
- Hypervolemia
- Severe burning, pain, or swelling around IV needle
- Warmth, redness, oozing, or bleeding at IV site
- Fever, ongoing cough
Precautions & warnings
- Caution in pregnancy, renal impairment, heart failure, pulmonary congestion
- Caution in patients receiving potassium-sparing diuretics
- Do not administer rapidly or for prolonged periods
Contraindications
- Kidney failure with diminished urine production (oliguria) or preventing urine production (anuria)
Drug interactions
- Potassium Chloride: Potassium-sparing diuretics, ACE inhibitors, ciclosporin, potassium-containing drugs
- Potassium Chloride (oral): Antimuscarinics delay gastric emptying
- Sodium Chloride: May affect serum concentrations of lithium
- Sodium Acetate: May affect absorption of certain drugs due to increased intra-gastric pH; may increase renal clearance of acidic drugs, prolong half-life of basic drugs
Food interactions
Not food-related (IV use).
Use in pregnancy
Use in Pregnancy: Caution during pregnancy; electrolyte imbalance may have detrimental effects; consult your doctor.
Use in lactation
Use in Lactation: Caution during breastfeeding; consult your doctor.
Pediatric use
Pediatric dose based on age and weight; consult your doctor.
Geriatric use
Caution required in elderly patients; consult your doctor.
Renal / hepatic impairment
Renal Impairment: Caution in kidney disease; electrolyte imbalance may be detrimental; consult your doctor.
Hepatic Impairment: Caution in liver disease; consult your doctor.
Overdose effects
Overdose may cause electrolyte imbalance and hypervolemia; treatment: stop infusion, electrolyte monitoring and correction.
Storage conditions
Store in a cool and dry place; keep out of reach of children.
Chemical structure
Potassium Chloride 0.1% + Sodium Acetate 0.65% + Sodium Chloride 0.5%