Generic
Rota Virus Live attenuated Oral Vaccine
2 brands available in the market
At a glance
Rotavirus Live Attenuated Oral Vaccine is used to prevent rotavirus gastroenteritis in infants and young children. It is administered orally in 2 doses starting from 6 weeks of age, with the second dose given after at least 4 weeks and before 24 weeks of age.
Description
Rotavirus is a major cause of severe acute gastroenteritis in infants and young children. There are 2 commercially available forms: a live, attenuated monovalent vaccine derived from human strain (prevents G1, G3, G4, G9 serotypes) and a live, pentavalent human-bovine reassortant vaccine (prevents G1, G2, G3, G4 serotypes). Vaccine viruses replicate in the small intestine and promote active immunity.
Indications
- Prevention of rotavirus gastroenteritis
Therapeutic class
Vaccine
Pharmacological class
Live Attenuated Vaccine
Pharmacology
Rotavirus vaccine viruses replicate in the small intestine and stimulate active immunity. The monovalent vaccine derived from human strain prevents rotavirus gastroenteritis caused by G1, G3, G4, G9 serotypes, while the pentavalent vaccine prevents disease caused by G1, G2, G3, G4 serotypes.
Mechanism of action
Prevents rotavirus infection by replicating in the small intestine and stimulating active immunity.
Dosage
Pediatric Dose (Oral):
- 2-Dose Regimen: Total of two 1 ml doses administered orally
- First dose: Starting at 6 weeks of age
- Second dose: At least 4 weeks after the first dose and before 24 weeks of age
Administration
- Administer orally
- May be taken with or without food
Missed dose
If you miss a dose, consult your doctor.
Side effects
Common Side Effects (>10%):
- Diarrhea (24.1%)
- Vomiting (15.2%)
- Otitis media (14.5%)
- Fever (17-43%)
- Fussiness/irritability (3-52%)
1-10%:
- Nasopharyngitis (6.9%)
- Bronchospasm (1.1%)
- Flatulence (2%)
Precautions & warnings
- Caution in history of chronic GI disorders, chronic diarrhea, congenital abdominal disorders, abdominal surgery
- Defer vaccination in acute diarrhea, vomiting, or severe febrile illness
- Monitor for signs of intussusception (severe abdominal pain, persistent vomiting, bloating, blood in stools, high fever)
- Monitor for Kawasaki disease symptoms (fever, rash, red eyes, red mouth, swollen hands/feet)
- Caution with non-vaccinated or immunodeficient contacts
Contraindications
- History of intussusception
- Severe Combined Immunodeficiency (SCID) disorder
Drug interactions
- Immunosuppressive therapies may diminish immune response to the vaccine
- Simultaneous immunization with other age-appropriate vaccines is not expected to interfere
Food interactions
Alcohol consumption is not relevant (pediatric vaccine).
Use in pregnancy
Use in Pregnancy: Not applicable; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Not applicable; consult your doctor.
Pediatric use
Indicated for infants (6 weeks to 24 weeks of age)
Geriatric use
Not applicable (pediatric vaccine)
Renal / hepatic impairment
Not applicable
Overdose effects
No overdose information available; consult your doctor.
Storage conditions
Store in a refrigerator at 2-8°C; protect from light; keep out of reach of children.
Chemical structure
Rotavirus Vaccine