Suxamethonium Chloride (Succinylcholine)

Suxamethonium Chloride (Succinylcholine) belongs to a group of medicines called muscle relaxants. It is used along with general anesthesia or sedatives to provide skeletal muscle relaxation during surgical procedures. It is also used to facilitate emergency airway management in patients in intensive care. Suxamethonium Chloride (Succinylcholine) is administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. The most common side effects of this medicine include If any of these side effects persist or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms. Before using it, to make sure it is safe for you, you should let your doctor know if you have any other medical conditions or disorders. You should also tell your doctor all the other medicines you are using or taking. Pregnant and breastfeeding women should consult their doctors before using this medicine. Suxamethonium Chloride (Succinylcholine) relaxes the muscles by blocking the impulses from the nerves.

• Skeletal mucle relaxation during surgery

Suxamethonium chloride is an ultrashort-acting depolarising type skeletal muscle relaxant. It blocks the neuromuscular junction by binding to the cholinergic receptors and depolarising it.

Adult Dose: Intravenous Muscle relaxant in general anaesthesia Adult: As suxamethonium Cl: Single dose of 0.3-1.1 mg/kg by inj. Supplementary doses of 50-100% of the initial dose may be given at 5-10 min intervals. For prolonged procedures, 0.1-0.2% soln by infusion at 2.5-4 mg/min, adjusted as necessary. Max (repeated inj or continuous infusion): 500 mg/hr. Intramuscular Muscle relaxant in general anaesthesia Adult: As suxamethonium Cl: 3-4 mg/kg. Max: 150 mg. Child Dose: Intravenous Muscle relaxant in general anaesthesia Child: As suxamethonium Cl: 1 yr Up to 4 mg/kg. Max: 150 mg.

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Common: • High blood pressure • Increased heart rate • Skin rash • Slow heart rate

[NOT RELEVANT] Not relevant, as Suxamethonium Chloride (Succinylcholine) is intended for use in hospitalised patients. Tell your doctor before using suxamethonium if you have or had tetanus, tuberculosis, other severe or long standing infection or illness, cancer, anemia, malnutrition, liver or kidney problems, auto-immune diseases (multiple sclerosis), an underactive thyroid gland (myxoedema), muscle disease (such as myasthenia gravis), a blood transfusion or a heart-lung by pass, been in contact with insecticides, allergic reaction to any muscle relaxant given as part of an operation. Suxamethonium paralyses the respiratory muscles as well as other skeletal muscles but has no effect on consciousness. You may experience some muscle pain after suxamethonium administration if you have undergone short surgical procedure under general anaesthesia. Do not drive or use machinery too soon after having an operation. Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Genetic disorders of plasma pseudocholinesterase, personal/family history of malignant hyperthermia, hypersensitivity from previous neuromuscular drug, severe burns, massive trauma, extensive denervation of skeletal muscle, patients with risk of hyperkalaemia, renal impairment, angle closure glaucoma.

Prolonged neuromuscular blocking effects w/ specific anticholinesterase agents (e.g. neostigmine), cytotoxic compd (e.g. cyclophosphamide), antiarrhythmics (e.g. quinidine), aminoglycosides, psychiatric drugs (e.g. chlorpromazine), Mg salts, anaesth agents (e.g. morphine), SSRIs, organophosphate insecticides. Increased susceptibility to the effects of suxamethonium-exacerbated hyperkalaemia w/ digitalis-like drugs.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Suxamethonium Chloride (Succinylcholine). Please consult your doctor.

[CONSULT YOUR DOCTOR] Suxamethonium Chloride (Succinylcholine) may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Suxamethonium Chloride (Succinylcholine) is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Suxamethonium Chloride (Succinylcholine) should be used with caution in patients with kidney disease. Dose adjustment of Suxamethonium Chloride (Succinylcholine) may be needed. Please consult your doctor. [CAUTION] Suxamethonium Chloride (Succinylcholine) should be used with caution in patients with liver disease. Dose adjustment of Suxamethonium Chloride (Succinylcholine) may be needed. Please consult your doctor.

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