Thalidomide

Thalidomide is used in the treatment of multiple myeloma and lepra reaction. This medicine belongs to a group of medicines which affect how your immune system works. Thalidomide should be taken on empty stomach, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Some common side effects of this medicine include headache, sleepiness, nausea, rash, and breathlessness. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections or bleeding. Regular blood tests are required to check your blood cells while on treatment. It might cause blood clots, and your doctor might prescribe some other medicine to prevent this. Before taking it, tell your doctor if have heart disease, liver, or kidney problems. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. You are advised to drink plenty of fluids to stay hydrated while taking this medicine. Thalidomide modulates the activity of body's immune system and helps indirectly attacking the cancer cells. It also stops the growth of blood vessels in cancer.

• Multiple myeloma • Lepra reaction

Thalidomide is a synthetic glutamic acid derivative immunomodulator with anti-inflammatory, antiangiogenetic, sedative and hypnotic activity.

Adult Dose: Oral Erythema nodosum leprosum (Type 2) Adult: 100-300 mg once daily at bedtime, reduced gradually by 50 mg every 2-4 wk once a satisfactory reponse is achieved. Not for monotherapy if moderate or severe neuritis present. Max: 400 mg/day. Patients < 50 kg: Initially, 100 mg daily. Multiple myeloma Adult: Initial dose of 200 mg once daily, increased by 100 mg at wkly intervals according to patient tolerance. Max: 800 mg daily.

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Thalidomide is to be taken empty stomach.

If you miss a dose of Thalidomide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Headache • Sleepiness • Nausea • Rash • Weakness • Dizziness • Edema (swelling) • Loss of appetite • Decreased white blood cell count • Decreased calcium level in blood • Weight gain • Fatigue • Muscle weakness • Fever • Anxiety • Blood clots • Dry skin • Weight loss • Confusion • Decreased white blood cell count (neutrophils) • Neuropathy • Constipation • Tremor

[UNSAFE] Thalidomide may cause side effects which could affect your ability to drive. You may experience side effects, such as dizziness, tiredness, sleepiness or blurred vision with Thalidomide and this may affect your ability to drive. Use an effective method of contraception for 4 weeks before starting treatment, during treatment, and until 4 weeks after stopping treatment. Before taking thalidomide inform your doctor if you have had a heart attack, have ever had a blood clotting related disorder, or if you smoke, have high blood pressure or high cholesterol levels, have existing slow heart rate (this may be symptoms of bradycardia), existing neuropathy i.e. tingling, abnormal co-ordination or pain in your hands or feet, sleepiness, a condition called Tumor Lysis Syndrome, severe infections. Consult a doctor if you develop allergic reaction such as rash, itching, swelling, dizziness or trouble breathing during thalidomide therapy. Avoid donating blood during thalidomide treatment and for 1 week after stopping treatment. Do not drive or operate machinery as thalidomide may cause fatigue, dizziness, somnolence and blurred vision. Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Hypersensitivity. Pregnancy and lactation.

Thalidomide enhances sedative activity of barbiturates, alcohol, chlorpromazine and reserpine. Avoid use of other drugs that have the potential to cause peripheral neuropathy. Increased risk of thromboembolic events with darbepoetin-alfa and doxorubicin. Potentially Fatal: Increased risk of bone marrow supression with peg interferon alfa.

[UNSAFE] Thalidomide may cause excessive drowsiness with alcohol.

[UNSAFE] Thalidomide is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

[CONSULT YOUR DOCTOR] Thalidomide is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[SAFE IF PRESCRIBED] Thalidomide is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Thalidomide may not be needed in these patients. Please consult your doctor. [SAFE IF PRESCRIBED] Thalidomide is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Thalidomide may not be needed in these patients. Please consult your doctor.

Is Thalix 100 mg capsule increases blood sugar of patient. No. Increased blood sugar not a common side effect of thalix. Please tell me the interpretation of the attach report, if possible. Also guide for further treatment process. U r having multiple myeloma Multiple myeloma can be cured or not Yes, if diagnosed at the right stage Pus disharge from maxilla.Patient has multiple myeloma Tooth exfoliated from the jaw post which this change was noted OPG reveals radiolucency in that site Visit to a dentist for proper treatment by surgery. Report shows higher esr value what should i do. A very high ESR usually has an obvious cause, such as a severe infection, marked by an increase in globulins, polymyalgia rheumatica or temporal arteritis. A health practitioner will typically use other follow-up tests, such as blood cultures, depending on the person&#x27;s symptoms. People with multiple myeloma or Waldenstrom&#x27;s macroglobulinemia (tumors that make large amounts of immunoglobulins) typically have very high ESRs even if they don&#x27;t have inflammationNeed to correlate clinicallyKindly consult your doctor Ganral enquiries about daly sex How to increase the reaction time take healthy food, more of urad daal, dry fruits, will help. Ashwgandha capsule 2 capsule twice with milk will help What is LENALIDOMIDE & why should it be taken ? Lenalidomide is a anti myeloma medicine i am having an allergy of sneezing and i had consulted doctor and dr. had given zeclox capsule and ellervil tablet so i want to know that is there any substitute of zeclox capsule bcoz its not available in local market or can u make zeclox capsule available on 1mg app? i&#x27;ll buy it in bulk Zeclox is combination of amoxicylline and dicloxacilline so u can search with salt and u will get multiple brands