Albumin Human 0.25

• Hypovolemia: To restore and maintain plasma volume when blood volume is reduced due to surgery, trauma, shock, or burns, particularly when crystalloids are inadequate. • Hypoalbuminemia: To correct low blood albumin levels caused by conditions such as liver cirrhosis, nephrotic syndrome, acute or chronic liver failure, malnutrition, and other conditions. • Paracentesis in Cirrhotic Ascites: To prevent paracentesis-induced circulatory dysfunction following the removal of large volumes of ascitic fluid. • Ovarian Hyperstimulation Syndrome (OHSS): As a plasma volume expander in severe OHSS to help prevent fluid shifts and ascites. • Adult Respiratory Distress Syndrome (ARDS): To correct fluid volume overload in combination with diuretics. • Burns: After 24 hours following a burn injury, once capillary permeability has stabilized, to assist in the reabsorption of edema. • Cardiopulmonary Bypass: As a priming fluid during extracorporeal bypass procedures to maintain colloid osmotic pressure. • Hemodialysis: In patients undergoing long-term dialysis or those with fluid overload. • Therapeutic Plasma Exchange: As a plasma replacement fluid during plasmapheresis procedures.

Human albumin is not a glycoprotein and has the lowest molecular weight (66,241 Daltons) of all plasma proteins, resulting in lower viscosity than other plasma proteins . Approximately 40% of albumin is in circulation; the remainder is in extravascular spaces of tissues (principally muscle, skin, and intestine) . The major function of albumin is osmotic regulation . The 25% solution is hyperoncotic, providing higher oncotic pressure per unit volume compared to 5% albumin . Following intravenous infusion, it increases plasma volume by approximately 3.5 times within 15 minutes .

Adult Dose: Adult: Initially, 25 g of albumin, adjusted according to patient's response. Usual rates of infusion: 1-2 ml/minute. Child Dose: Child: Up to 1 g/kg, adjusted according to patient's response. Usual rates of infusion: 1-2 ml/minute. Not to exceed 250 g/48 hr or 6 g/kg/day

Common: • Vomiting • Flushing (sense of warmth in the face, ears, neck and trunk) • Fever • Nausea • Chills • Hives • Slow heart rate

[CONSULT YOUR DOCTOR] Albumin Human 25% may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE] Albumin Human 25% does not usually affect your ability to drive. It is given as an injection into veins under the supervision of a medical professional. Inform your doctor immediately if you experience a skin rash, itching, breathing difficulties, swelling of face and changes in heartbeat while using this medicine. Inform your doctor if you have history of severe anemia (lack of red blood cells), or severe heart failure.

• Overdose may cause hypervolemia (circulatory overload), which may present with headache, shortness of breath, jugular vein distension, increased blood pressure, and pulmonary edema. • At the first signs of circulatory overload, stop the infusion and monitor hemodynamic parameters.

• Store below 30°C, protected from light. • Keep in the original carton. • Do not freeze. • The solution must be clear at the time of use. • Keep out of reach of children.