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Glimepiride is a medicine used to treat type 2 diabetes mellitus in adults. It belongs to a group of medicines called sulfonylureas and helps control blood sugar levels in people with diabetes. This helps to prevent serious complications of diabetes like kidney damage and blindness. Glimepiride may be used alone or along with other medicines. It should be taken just before or with the first meal of the day. Take it regularly at the same time each day to get the maximum benefit. Your doctor will decide what dose is best for you and this may change from time to time according to your blood sugar levels. Keep taking this medicine, even if you feel well or your blood sugar levels are controlled. If you stop it without consulting your doctor, your blood sugar levels could rise and put you at risk of kidney damage, blindness, nerve problems and loss of limbs. Remember that it is only part of a treatment program that should also include a healthy diet, regular exercise and weight reduction as advised by your doctor. Your lifestyle plays a big part in controlling diabetes. The most common side effects of taking this medicine include low blood sugar levels (hypoglycemia), nausea, headache, and dizziness. Make sure you recognize the signs of having low blood sugar levels, such as sweating, dizziness, headache, and shaking and know how to deal with them. To prevent this, it is important to have regular meals and always carry a fast-acting source of glucose such as sugary food or fruit juice with you. Drinking alcohol can also increase your risk of low blood sugar levels and hence should be avoided. Some people may experience an increase in weight with this medicine. You should not take it if you have type 1 diabetes mellitus, diabetic ketoacidosis (high levels of acid in your blood), or if you have severe kidney or liver disease. Before taking this medicine, tell your doctor if you have ever had heart disease, thyroid disease or some hormonal conditions, as it may not be suitable. Pregnant or breastfeeding women should also consult their doctor before taking it. Your blood sugar levels should be checked regularly and your doctor may also advise blood tests to monitor your blood cell counts and liver function. Glimepiride is an antidiabetic medication. It works by increasing the amount of insulin released by the pancreas in order to lower blood glucose.

• Type 2 diabetes mellitus

Glimepiride stimulates the insulin release from pancreatic beta-cells and reduces glucose output from the liver. It also increases insulin sensitivity at peripheral target sites.

Adult Dose: Oral Type 2 diabetes mellitus Adult: Initially, 1-2 mg daily. May be increased in increments of 1-2 mg at intervals of 1-2 wk. Maintenance: 4 mg daily. Max: 6 mg daily. Elderly: Initially, 1 mg once daily. Hepatic impairment: Severe: Contraindicated. Child Dose: Safety and efficacy not established Renal Dose: Renal impairment: 1 mg PO qDay; titrate dose based on fasting blood glucose levels Severe: Contraindicated.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Glimepiride is to be taken with food.

You should skip a dose of Glimepiride if a meal is skipped, and add a dose of medicine if you eat an extra meal.

Common: • Hypoglycemia (low blood glucose level) • Headache • Nausea • Dizziness

[CAUTION] Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur. Take it shortly before or with the first main meal of the day (usually breakfast). Avoid skipping meals. Exercise regularly, eat a healthy diet and take your other diabetes medicines (if prescribed) alongside. Monitor your blood sugar level regularly while you are taking this medicine. Be careful while driving or operating machinery until you know how Glimepiride affects you. It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor and anxiety. Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms, such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).

Diabetic ketoacidosis with or without coma.

Salicylates, sulfonamides, chloramphenicol, clarithromycin, coumarin anticoagulants, probenecid, CYP2C9 inhibitors, fibric acid derivatives, disopyramide, fluoxetine, quinolones, ACE inhibitors, MAOIs and ?-blockers may potentiate the hypoglycaemic action of glimepiride. Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, oestrogens, phenytoin, nicotinic acid, sympathomimetics and CYP2C9 inducers may reduce hypoglycaemic effect of glimepiride. Reduced plasma concentration w/ colesevelam.

[UNSAFE] It is unsafe to consume alcohol with Glimepiride.

[CONSULT YOUR DOCTOR] Glimepiride may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Glimepiride is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. Monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with Glimepiride

[CAUTION] Glimepiride should be used with caution in patients with kidney disease. Dose adjustment of Glimepiride may be needed. Please consult your doctor. Use of Glimepiride is not recommended in patients with severe kidney disease. These patients can experience very low blood sugar levels which may become normal after a long time. [CAUTION] Glimepiride should be used with caution in patients with liver disease. Dose adjustment of Glimepiride may be needed. Please consult your doctor. Use of Glimepiride is not recommended in patients with severe liver disease. These patients can experience very low blood sugar levels which may become normal after a long time.

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