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At a glance

Lasmiditan is used for the acute treatment of migraine with or without aura in adults. It is a potent and selective 5-HT1F receptor agonist that inhibits trigeminal nerve pathway activation.

Indications
  • Acute treatment of migraine with or without aura in adults
Pharmacology

Lasmiditan inhibits trigeminal nerve firing through agonism at 5-HT1F receptors. It works without relying on cerebral vasoconstriction (supporting the neurogenic hypothesis as an alternative to the vascular hypothesis).

Dosage

Adult Dose (Oral):

  • 50 mg, 100 mg, or 200 mg as needed
  • No more than one dose in 24 hours
  • Do not drive or operate machinery for at least 8 hours after dosing
  • May be taken with or without food

Hepatic Impairment: Severe (Child-Pugh C): Not recommended

Side effects

Common Side Effects:

  • Dizziness
  • Fatigue
  • Paresthesia
  • Sedation
Use in pregnancy

Use in Pregnancy: No adequate data in pregnant women. Animal studies have shown adverse effects. Use only if clearly needed.

Precautions & warnings
  • Do not drive or operate machinery for at least 8 hours after each dose
  • Caution with CNS depression (use with alcohol or other CNS depressants)
  • Monitor for serotonin syndrome (with SSRIs, SNRIs, TCAs, MAO inhibitors)
  • Caution with heart rate-lowering drugs
Overdose effects

No specific overdose information available; symptomatic and supportive measures should be employed.

Storage conditions

Store below 30°C, away from light and moisture; keep out of reach of children.

Lasmiditan Hemisuccinate — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.