Neureliv 50

Epalrestat is used to treat diabetic nerve pain. Poorly controlled diabetes can eventually lead to diabetic nerve disease (neuropathy) as a complication. This medicine helps to relieve symptoms like burning pain and numbness seen in people with diabetic nerve disease. Epalrestat belongs to a group of medicines known as Aldose reductase inhibitors. It can be taken with or without food but you should try to take it at the same time every day. This will help you to remember to take it. The dose and how often you need it will be decided by your doctor so that you get the right amount to control your symptoms. It may take up to 3 months to get the full benefits of this medicine, but you should keep taking it regularly. Do not stop taking it without asking your doctor, otherwise, your condition may worsen. This medicine is only part of a treatment program that should also include a healthy diet, regular exercise, and weight reduction as advised by your doctor. You should also continue taking other medicines prescribed by your doctor for blood sugar control. Keeping your blood sugar levels under control will help this medication work better. The most common side effects of this medicine include nausea, vomiting, and abnormalities in liver function tests (increased liver enzymes). Most side effects are temporary and improve as your body gets used to the medicine. Please consult your doctor if any of these bother you or do not go away. Before taking this medicine, let your doctor know if you have any kidney or liver problems. Pregnant or breastfeeding women should also consult their doctor before taking this medicine. Avoid any alcohol intake while taking it as this may increase the risk of developing some side effects. Epalrestat is an aldose reductase inhibitor. It blocks the accumulation of sorbitol in cells, which has been related to causing diabetic nerve disease.

• Diabetic nerve pain

Epalrestat is aldose reductase inhibitor. The aldose reductase inhibitors have a distinct mechanism of action, affecting the underlying disease process in diabetic neuropathy, although the extent of the polyol pathway involvement is yet to be determined. Epalrestat reduces sorbitol accumulation in the sciatic nerve, erythrocytes. Epalrestat may improve motor and sensory nerve conduction velocity and subjective neuropathy symptoms.

Adult Dose: Oral Diabetic neuropathy Adult: 50 mg tid.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Epalrestat may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Epalrestat, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Nausea • Vomiting • Abnormal liver function

[CONSULT YOUR DOCTOR] It is not known whether Epalrestat alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Adherence to antidiabetic therapy can delay the onset of or prevent diabetic nerve disease. If you have existing diabetic nerve disease, wear proper footwear and examine your feet every day to detect lesions early. If you have a foot injury or open wound, avoid engaging in weight-bearing activities.

Hypersensitivity. Pregnant or breastfeeding.

[UNSAFE] It is unsafe to consume alcohol with Epalrestat.

[CONSULT YOUR DOCTOR] Information regarding the use of Epalrestat during pregnancy is not available. Please consult your doctor.

[CONSULT YOUR DOCTOR] Information regarding the use of Epalrestat during breastfeeding is not available. Please consult your doctor.

[CONSULT YOUR DOCTOR] There is limited information available on the use of Epalrestat in patients with kidney disease. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Epalrestat in patients with liver disease. Please consult your doctor.

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