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Nateglinide is used to lower blood sugar levels in adults with type 2 diabetes mellitus. It is usually prescribed along with other diabetes medicines to achieve adequate blood sugar control. It also prevents serious complications of diabetes like kidney damage and blindness. Nateglinide is normally prescribed when diet and exercise alone or other medicines have not been enough to control your blood sugar level. It works best when taken before meals. The dose will depend on your condition, and blood sugar levels, but you should use it as advised by your doctor. You should take it regularly, at the same time each day, to get the most benefit and you should not stop unless your doctor recommends it. It is controlling your blood sugar levels and helping to prevent serious complications in the future. It is important to stay on the diet and exercise program recommended by your doctor while taking this medicine. Your lifestyle plays a big part in controlling diabetes. The most common side effect of taking this medicine is low blood sugar level (hypoglycemia). You can carry sugar or glucose candy to control low blood sugar level. Other side effects that may be seen while taking this medicine include dizziness, back pain, and flu-like symptoms. Contact your doctor if the side effects worry you or if they do not go away. Before taking this medicine, let your doctor know if you have ever had kidney disease, heart or pancreas problems, or if you drink a lot of alcohol. Pregnant or breastfeeding women should also consult their doctor before taking it. Some other medicines you are taking may interfere with it so make sure your doctor knows about all the other medicines you are using. Limit your alcohol intake while taking this medicine because it can increase your risk of developing low blood sugar levels. You may need regular tests such as kidney function and blood glucose levels to check that the medicine is working properly. Nateglinide is an anti-diabetic medication. It increases the amount of insulin released by the pancreas which prevents blood glucose from rising very high after meals.

• Type 2 diabetes mellitus

Nateglinide, a nonsulfonylurea hypoglycaemic agent, acts by stimulating insulin release from pancreatic ?-cells to reduce postprandial hyperglycaemia. This action depends on the amount of existing glucose levels.

Adult Dose: Oral Type 2 diabetes mellitus Adult: 60 or 120 mg tid.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nateglinide is to be taken empty stomach.

If you miss a dose of Nateglinide, skip it and continue with your normal schedule. Do not double the dose.

Common: • Hypoglycemia (low blood glucose level) • Dizziness • Increased appetite • Increased heart rate • Nausea • Sweating • Tiredness • Weakness

[CAUTION] Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur. It may cause dizziness. Do not drive or do anything that requires mental focus until you know how Nateglinide affects you. It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor, and anxiety. Monitor your blood sugar levels regularly while you are taking this medicine. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Diabetic ketoacidosis; IDDM. Lactation.

Increased levels/effects with enzyme inhibitors (e.g. fluconazole). Increased hypoglycaemic effects with salicylates, MAOIs, nonselective beta-blockers, alcohol, NSAIDs. Decreased levels/effects with enzyme inducers (e.g. rifampicin). Decreased hypoglycaemic effects with thiazide diuretics, corticosteroids, thyroid products and sympathomimetic agents.

[UNSAFE] It is unsafe to consume alcohol with Nateglinide.

[CONSULT YOUR DOCTOR] Nateglinide may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Nateglinide is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. Monitor the breastfed baby’s blood sugar during treatment with Nateglinide

[SAFE IF PRESCRIBED] Nateglinide is safe to use in patients with kidney disease. No dose adjustment of Nateglinide is recommended. [CAUTION] Nateglinide should be used with caution in patients with liver disease. Dose adjustment of Nateglinide may be needed. Please consult your doctor. Limited data are available on the use of Nateglinide in patients with moderate to severe liver disease.

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