QF 400 Quatrefolic (6S 5-Methyltetrahydrofolate)400mcg

6s-5-methyltetrahydrofolate is a 4th-generation active folate derivative combined with glucosamine salt, offering superior bioavailability, safety, and stability compared to traditional folic acid.

Indicated during pregnancy & lactation to prevent neural tube defects and spontaneous abortions; dietary supplement for adults and postmenopausal women; managing medication-induced or dialysis-induced folate deficiency; and support in depression, cognitive impairment, dementia, and Alzheimer's disease.

Herbal and Nutraceuticals

Water-soluble Vitamin B / Active Folate Derivative

6s-5-methyltetrahydrofolate functions as a coenzyme in DNA/RNA synthesis and amino acid metabolism. Its active glucosamine salt form ensures immediate metabolic utilization without enzymic reduction.

Directly donates methyl groups required for homocysteine remethylation to methionine and essential DNA synthesis.

1-2 Capsules daily or as directed by the physician.

Take orally with water, with or without food, as directed.

Take as soon as remembered. Skip if it is almost time for the next scheduled dose.

Generally well-tolerated. Rarely, gastrointestinal disturbances (nausea, flatulence, abdominal distension) or hypersensitivity reactions (rash, erythema, pruritus) may occur.

Inadequate as monotherapy for pernicious anemia and Vitamin B12 deficiency as it may obscure neurological manifestations.

Contraindicated in patients with known hypersensitivity to any of the ingredients.

Antagonizes phenytoin action. Methotrexate, anticonvulsants (phenobarbital, primidone), alcohol, and amiodarone may interact.

Alcohol impairs folate absorption and utilization.

Safely acceptable during pregnancy to prevent birth defects.

Pregnancy Category: A — always consult a doctor before taking during pregnancy.

Compatible with breastfeeding; actively secreted in breast milk.

Use in pediatric patients should be determined by a healthcare provider.

Safe and beneficial for older adults to maintain homocysteine balance and cognitive health.

Indicated in patients undergoing renal dialysis to replenish lost folate.

In case of accidental overdose, seek immediate medical facility reference.

Store below 25°C in a dry place protected from light. Keep out of reach of children.

6S-5-methyltetrahydrofolate glucosamine salt (C20H25N7O6)

Question: Why is 6s-5-methyltetrahydrofolate preferred over regular folic acid? Answer: It is already in its active metabolic form, ensuring higher bioavailability and effectiveness regardless of MTHFR gene mutations. Question: Is it safe during pregnancy? Answer: Yes, it is safely acceptable and recommended to prevent neural tube defects.