৳ 9/unit
Pack: ৳ 45
৳ 9/unit
Pack: ৳ 45
At a glance
Prochlorperazine Mesilate is a dopamine antagonist used for nausea, vomiting, Meniere's disease vertigo, and schizophrenia. It blocks dopamine receptors in the chemoreceptor trigger zone for antiemetic effects and mesolimbic dopamine receptors for antipsychotic effects.
Indications
- Nausea
- Vomiting
- Vertigo
- Meniere's disease
- Schizophrenia
Pharmacology
Prochlorperazine blocks dopamine receptors in the chemoreceptor trigger zone for antiemetic effects and mesolimbic dopamine receptors for antipsychotic effects. It also blocks α-adrenergic receptors in the brain.
Dosage
Adult Dose (Oral):
- Antiemetic prophylaxis: 5-10 mg 2-3 times daily
- Nausea/vomiting: 20 mg, repeat if needed
- Psychosis: 12.5 mg twice daily for 7 days, gradually increase to 75-100 mg/day; maintenance 25-50 mg/day
- Severe anxiety: 5-10 mg up to 3-4 times daily
- Vertigo: 15-30 mg/day in divided doses; reduce to 5-10 mg/day
Parenteral (IV/IM):
- Nausea/vomiting: 12.5 mg deep IM; oral doses if needed
- Psychosis: 12.5-25 mg deep IM 2-3 times daily
Pediatric Dose (Oral):
- Psychosis (1-5 years): 1.25-2.5 mg; (5-12 years): 2.5-5 mg; up to 3 times daily if needed
Side effects
Common Side Effects:
- Drowsiness
- Orthostatic hypotension
- Muscle spasms
- Tongue movements
- Restlessness
- Tremors
- Skin rash
Use in pregnancy
Use in Pregnancy: Information regarding use during pregnancy is not available; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May affect driving ability; do not drive if drowsy or dizzy
- Avoid alcohol (excessive drowsiness)
- May increase sensitivity to sunlight; avoid prolonged sun exposure
- May reduce sweating (risk of heatstroke)
Overdose effects
Overdose: Deep sleep, coma, extrapyramidal symptoms, abnormal involuntary muscle movements, hypotension.
Storage conditions
Store in a cool and dry place; keep out of reach of children.