Generic
Metoprolol Tartrate
30 brands available in the market
At a glance
Metoprolol Tartrate is a beta-blocker used to treat hypertension angina arrhythmia and prevent migraine.
Description
Metoprolol Tartrate is a selective beta1-blocker that works on the heart. It reduces the agonistic effect of catecholamines on the heart resulting in decreased heart rate cardiac output and blood pressure. It slows heart rate and makes the heart more efficient at pumping blood.
Indications
- Hypertension
- Angina pectoris
- Arrhythmia
- Migraine prevention
- Adjunct in hyperthyroidism
- Acute myocardial infarction
Therapeutic class
Beta-blockers
Pharmacological class
Cardioselective Beta-blocker
Pharmacology
Metoprolol is a selective beta1-blocker. It reduces the agonistic effect of catecholamines on the heart resulting in decreased heart rate cardiac output and blood pressure. It interferes less with insulin release and carbohydrate metabolism than non-selective beta-blockers.
Mechanism of action
Slows heart rate and lowers blood pressure to improve heart function.
Dosage
Adult Dose (Oral):
- Hypertension: Initial: 100 mg/day; may increase to 400 mg/day; Maintenance: 100-200 mg/day
- Angina: 50-100 mg 2-3 times daily
- Arrhythmias: 50 mg 2-3 times daily; may increase to 300 mg/day
- Hyperthyroidism: 25-50 mg 4 times daily
- Migraine Prophylaxis: 100-200 mg/day
- Heart Failure: Initial: 12.5-25 mg/day; Target: 200 mg/day
Child Dose: 1-2 mg/kg/day; Max: 6 mg/kg or 200 mg/day
Administration
- Take with food
- Swallow tablet whole
- Take at the same time each day
Missed dose
If you miss a dose take it as soon as you remember; skip if its almost time for next dose; do not double the dose.
Side effects
Common Side Effects:
- Orthostatic hypotension
- Slow heart rate
- Headache and dizziness
- Fatigue and tiredness
- Stomach pain and nausea
- Breathlessness
Precautions & warnings
- Caution while driving
- Rise slowly from sitting or lying position
- Monitor glucose if diabetic
- Do not stop abruptly
- Caution in liver problems
Contraindications
- 2nd or 3rd degree AV block
- Sick sinus syndrome
- Hypotension
- Decompensated heart failure
- Sinus bradycardia
- Severe peripheral arterial disorders
- Cardiogenic shock
- Severe asthma and bronchospasm
Drug interactions
- Catecholamine-depleting drugs: Additive effect
- CYP2D6 Inhibitors: Increased plasma concentrations
- Digitalis glycosides: Increased risk of bradycardia
- Clonidine: Rebound hypertension on withdrawal
Food interactions
Alcohol with Metoprolol Tartrate may increase dizziness.
Use in pregnancy
Use in Pregnancy (Category C): Possibly unsafe. Your doctor will weigh benefits and risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Probably unsafe. Metoprolol is excreted in breast milk in small quantities.
Pediatric use
Dose established for children 6-16 years; not established in children <6 years.
Geriatric use
No specific dose adjustment required for elderly.
Renal / hepatic impairment
Renal Impairment: Safe - no dose adjustment required.
Hepatic Impairment: Safe - no dose adjustment required.
Overdose effects
Overdose may cause severe hypotension sinus bradycardia AV block heart failure cardiogenic shock bronchospasm coma. Symptomatic treatment.
Storage conditions
Store in a cool and dry place protected from light. Keep out of reach of children.
Chemical structure
Metoprolol Tartrate