Flurom Plus

• Keratitis, Iridocyclitis, Iritis: Used for inflammatory conditions of the eye.
• Acute and Chronic Conjunctivitis: Used for allergic non-infectious conjunctivitis and keratitis.
• Post-operative Conditions: Used for irritative conditions after strabotomy, cataract and glaucoma surgery.

Fluorometholone is thought to act by the induction of phospholipase A2 inhibitory proteins which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. On the other hand, Tetrahydrozoline is an alpha agonist which constricts the conjunctival blood vessels and thereby relieves the redness of the eye.

Adult Dose (Ophthalmic):

• Instill 1 drop into the conjunctival sac 2-3 times daily.
• Dose may be increased to 1 drop hourly for first one to two days in severe cases.

Child Dose: Safety and effectiveness in children below 2 years have not been established.

Side Effects:

• Mild burning sensation
• Reversible increase in intraocular pressure
• Reactive hyperemia/rebound effect
• Cataract and corneal defects
• Glaucoma
• Systemic effects (chronic use)

Use in Pregnancy: No adequate and well-controlled studies; should be used only if potential benefits justify potential risk to the fetus.

Precautions:

• Prolonged use in pregnant women and infants should be avoided.
• Use with caution in patients under treatment with MAO inhibitors.
• Do not apply while wearing soft contact lenses; remove lenses before application and do not reinsert earlier than 15 minutes after use.
• Avoid prolonged use.

Overdose: Overdose is unlikely when used as directed; accidental ingestion: activated charcoal, gastric lavage, artificial ventilation with oxygen, phentolamine to lower blood pressure.

Storage: Store in a cool, dry place, away from heat and direct light. Keep out of reach of children. Do not use more than 4 weeks after opening.