Fondaparinux

Fondaparinux is an anticoagulant medicine used in the treatment of deep vein thrombosis (clot in veins of leg) and pulmonary embolism (clot in artery of lungs). It helps to prevent formation of harmful blood clots in blood vessels. Fondaparinux also reduces the risk of getting clots in people who have undergone knee or hip replacement surgeries, or who have been bedridden for long. It is administered under the supervision of a doctor. Your doctor will decide the dose and duration of the medicine for you. You should continue all your other medicines that are advised by the doctor for your long-term treatment even after this injection. Use of this medicine may increase your risk of bleeding. Let your doctor know immediately if you see pinpoint rash or blood in your vomits, urine, or stool. Before taking it, you must inform the doctor if you are suffering from any bleeding disorder, kidney or liver disease. Also, let your doctor know if you are pregnant or breastfeeding and about all the other medications that you are taking regularly. Fondaparinux is an anticoagulant. It stops the action of a substance (clotting factor Xa) from working in the blood. This prevents the formation of unwanted blood clots (thrombosis) in the blood vessels.

• Deep vein thrombosis • Pulmonary embolism

Fondaparinux, a synthetic pentasaccharide, acts as a selective inhibitor of activated factor X. It works by binding selectively to ATIII, and potentiates the neutralisation of Factor Xa. This will interrupt the blood coagulation cascade and inhibit both thrombin formation and thrombus development. At the recommended dosage, fondaparinux does not affect fibrinolytic activity or platelet function. It cannot lyse established thrombi and does not affect clotting function tests (e.g. aPPT, INR).

Adult Dose: Deep Vein Thrombosis/Acute Pulmonary Embolism Treatment 100 kg: 10 mg SC once daily Administer for 5-9 days; up to 26 days administered in clinical trials Prophylaxis >50 kg: 2.5 mg SC once daily for 5-9 days or up to 10 days following abdomonal surgery; for hip replacement, 11 days recommended and a minimum 10-14 days recommended for patients undergoing total hip or knee arthroplasty, or hip fracture surgery; administered for up to 35 days in some instances Child Dose: Safety and efficacy not established Renal Dose: Renal impairment: CrCl (ml/min) Dosage Recommendation <20 Contraindicated. 20-50 1.5 mg once daily.

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Fondaparinux, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Bleeding • Anemia (low number of red blood cells)

[CONSULT YOUR DOCTOR] It is not known whether Fondaparinux alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Fondaparinux prevents the formation of blood clots in the blood vessels of legs or lungs. It may make you feel dizzy, tired or weak. Do not drive or do anything that requires mental focus until you know how it affects you. It increases your risk of bleeding. Be careful while shaving, cutting fingernails or toenails, or using sharp objects. Notify your doctor if you see blood in your vomit, urine or stool (black, tarry stools or bright red blood). Do not discontinue use without consulting your doctor as this may increase your chances of having another heart attack or stroke.

Hypersensitivity. Active clinically significant bleeding, acute bacterial endocarditis.

Increased risk of bleeding w/ (e.g. desirudin, fibrinolytic drugs, glycoprotein IIb/IIIa-receptor antagonists, heparin, heparinoids or LMWH).

[UNSAFE] It is unsafe to consume alcohol with Fondaparinux.

[SAFE IF PRESCRIBED] Fondaparinux is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[SAFE IF PRESCRIBED] Fondaparinux is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Fondaparinux should be used with caution in patients with kidney disease. Dose adjustment of Fondaparinux may be needed. Please consult your doctor. Use of Fondaparinux is not recommended in patients with severe kidney disease. [CAUTION] Fondaparinux should be used with caution in patients with severe liver disease. Dose adjustment of Fondaparinux may be needed. Please consult your doctor.

Deep vein thrombosis , swelling nd painful in both leg. You need to take a surgical consultation Looking for a specialist in Deep vein thrombosis preferably in Kochi See a vascular surgeon In road accident head and small intestine got injured . 15 stiches on head and operation of 1 inch diameter of intestine . Now spo2 level is dropping to 70% after 1 hour of removing oxygen mask Get checked for pulmonary embolism or pneumothorax GE my self v.k tiwari mbbs md i feel the patient information above is there any blood test for diagnosed pulmonary edema and pulmonary embolism Dear Sir There is no specific blood test for diagnosing pulmonary edema and embolism Thrombosis involving both main pulmonary arteries and branches . Sir the patent has been chest pain with thrombosis pulmonary in both arteries n branch So what is the solution n treatment for this patent Need to see you in person.can meet me at medanta.call 9XXXXXX I am suffering from pulmonary embolism. I want to know will i die because of this disease ? What is d extent of your disease My Lungs operation on 2012 april.Trobo Entartectome The Right and left preliminary have Trombus Doctor Remove the trobus.Left side is more.PTINR level For 10 Days 2.2 TO 2.6 Now the days left chest side and Right side is always pain.Ecg checked. Bp.110/80.pulse 76.all relevent medical bloodl test ok.Pl Advice me return email I look have to receive your reply.Thank you.Jwala.m.m.If need I will forward you my all test reports Tab.Asitrom.5.5mg.Atorbrst.20.Fruselac Ds Tab.Caverta Sildinafil Tab.8mg 3 times Every Day.Digoxin.0.25mg. dear Mr Jwala. Your condition is coomplex. Pain after pulmonary embolism may be due to lung infarcts. please discuss with treating cardiologist and pulmonologist I think I have symptoms of dvt(deep vein thrombosis) I have features like deep pain in ankle knees and under feet very warmth compared to body temperature how can I get overcome from that can u pls kindly suggest Do exercises of calf muscles eg Heel raise etc.