৳ 1.20/unit
Pack: ৳ 1.20
৳ 1.20/unit
Pack: ৳ 1.20
At a glance
Primaquine is an antiparasitic medication used for radical cure of vivax and ovale malaria, as a gametocytocidal drug in P. falciparum infections, and for terminal prophylaxis after leaving a malarious area. It eliminates the exoerythrocytic forms of the malaria parasite.
Indications
- Radical cure of P. vivax and P. ovale malaria
- Gametocytocidal drug in P. falciparum infections
- Terminal prophylaxis after leaving a malarious area
Pharmacology
Primaquine disrupts mitochondria and binds to DNA, eliminating exoerythrocytic forms of malaria parasites. It provides radical cure for P. vivax and P. ovale, preventing relapses, and destroys P. falciparum gametocytes to prevent transmission.
Dosage
Adult Dose (Oral):
- P. vivax/ovale malaria: 30 mg/day for 14 days with chloroquine
- Uncomplicated P. vivax/ovale: 45 mg/day for 8 weeks (mild G6PD deficiency)
- Chemoprophylaxis: 30 mg/day for 14 days after leaving malaria-endemic area
- Gametocytocide: 30-40 mg single dose
Pediatric Dose (Oral):
- P. vivax/ovale malaria: 0.5 mg/kg/day (max 30 mg/day) for 14 days
- Chemoprophylaxis: 0.5 mg/kg/day (max 30 mg/day); start 1-2 days prior to travel and continue for 7 days after departure
Side effects
Side Effects:
- Abdominal pain and gastric distress (on empty stomach)
- Nausea, vomiting
- Methemoglobinemia (occasional)
- Hemolytic anemia (in G6PD deficiency)
- Headache
- Dizziness
- Rash
Use in pregnancy
Use in Pregnancy: Unsafe during pregnancy; definite evidence of risk; may cause transplacental hemolytic anemia in G6PD-deficient fetus.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May affect driving ability; do not drive if drowsy or dizzy
- Test for G6PD deficiency; discontinue if signs of hemolysis occur
- Monitor blood sugar in diabetic patients
- Monitor blood cell counts with long-term use
Overdose effects
Overdose: Abdominal cramps, vomiting, epigastric distress, CNS and cardiovascular disturbances, cardiac arrhythmia, QT prolongation, cyanosis, methemoglobinemia, granulocytopenia, acute hemolysis (G6PD); treatment: discontinue drug.
Storage conditions
Store at 25°C; protect from light.