Kanaprim15mg
Rx- Generic:
- Primaquine
- Company:
- Globe Pharmaceuticals Ltd.
- Dosage form:
- Tablet
- Pack size:
- Tablet
৳ 1.20/unit
Pack: ৳ 1.20
At a glance
Primaquine — brands, prices, indication, dosage and side effects available in Bangladesh.
Description
Primaquine is an antiparasitic medicine, used for the prevention and treatment of malaria. It works by killing malaria causing parasite and stops the infection from spreading. Primaquine should be used in the dose and duration as advised by your doctor. Take it with food to decrease the risk of stomach upset. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early can result in treatment failure and increase the side effects too. Do not take a double dose to make up for a missed dose. Simply take the next dose as planned. Take measures to reduce the chance of being bitten by mosquitoes like using insect repellent creams on parts of your body, not covered by clothing. Spray mosquito repellent to kill any mosquitoes that may have entered rooms in spite of screening. Wear light-colored and covered clothing when you are outside after sunset. Some people may have a rash, headache, vomiting, and dizziness, as side effects of this medicine. Please consult your doctor if these side effects persist for a longer duration. Inform your doctor if you have diabetes as it can lower the sugar levels in the blood. If you are diabetic, you should monitor your blood sugar regularly. It may cause blurring of vision. Therefore, regular eye examinations are recommended while on treatment with this medicine. When used long term, your doctor may monitor the amounts of the different types of blood cells in your blood regularly. Inform your doctor if you have unexplained bruising or bleeding, sore throat, fever, or a general feeling of tiredness. Primaquine is a an antiparasitic medication which treats malaria. It works by increasing the levels of haeme in the blood, a substance toxic to the malarial parasite. This kills the parasite and stops the infection from spreading.
Indications
• Malaria
Mechanism of action
Primaquine is an 8-aminoquinoline antimalarial which eliminates the exoerythrocytic forms of malarial parasite P.vivax, P. falciparum by disrupting mitochondria and binding to DNA. By this action primaquine achieves radical cure of vivax malaria. It is also active against gametocytes of P.falciparum.
Dosage
Adult Dose: Oral Prevention of relapse of P. vivax malaria 30 mg PO qDay for 14 days Uncomplicated P. vivax and P. ovale malaria 30 mg PO qDay for 14 days with chloroquine or hydroxychloroquine Alternatively, for mild G6PD deficiency or as alternative to daily regimen: 45 mg PO qDay for 8 weeks (only to be used after consultation with an infectious disease/tropical medicine expert Chemoprophylaxis P. vivax and P. ovale maleria: 30 mg PO qDay for 14 days after departure from malaria-endemic area Child Dose: Oral Uncomplicated P. vivax and P. ovale malaria 0.5 mg/kg (30 mg/day maximum) qDay for 14 days with chloroquine or hydroxychloroquine Chemoprophylaxis 0.5 mg/kg PO qDay (30 mg/day maximum); start 1-2 days prior to travel and continue for 7 days after departure from malaria endemic area
Administration
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Primaquine is to be taken with food.
Side effects
Common: • Rash • Vomiting • Headache • Dizziness • Hives • Stomach pain • Nausea • Abdominal pain • Itching • Heartburn • Gastrointestinal discomfort • Upper abdominal pain
Precautions & warnings
[UNSAFE] Primaquine may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Primaquine is used for the prevention and treatment of malaria. Take it with food to decrease the risk of stomach upset. Tips to reduce the chance of being bitten by mosquitoes: It may cause blurring of vision, when you first start taking it. Use caution while driving or doing anything that requires concentration. Eye examination prior to and at 3–6 monthly intervals during use is required if patients are receiving Primaquine at continuous high doses for longer duration. It may cause low blood sugar level. Monitor your blood sugar level regularly, if you are diabetic. When used long term, your doctor may monitor the amounts of the different types of blood cells in your blood regularly. Inform your doctor if you have unexplained bruising or bleeding, sore throat, fever, or general feeling of tiredness.
Contraindications
Hypersensitivity. Childn <1 yr. Acute flare-ups of systemic diseases (RA, SLE) having tendency for agranulocytopaenia, Pregnancy and lactation.
Drug interactions
Primaquine may inhibit metabolism of chloroquine. Avoid ethanol. Potentially Fatal: Mepacrine may potentiate toxicity of primaquine. Potentially haemolytic drugs eg, sulphonamides, nitrofurans and bone marrow suppressants eg, methotrexate, phenylbutazone, chloramphenicol should not be co-admin with primaquine.
Food interactions
[UNSAFE] It is unsafe to consume alcohol with Primaquine.
Use in pregnancy
[CONSULT YOUR DOCTOR] Primaquine is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Use in lactation
[SAFE IF PRESCRIBED] Primaquine is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Renal / hepatic impairment
[CONSULT YOUR DOCTOR] There is limited information available on the use of Primaquine in patients with kidney disease. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Primaquine in patients with liver disease. Please consult your doctor.
Common questions
Having high fever and little chest congestion, college gave levatos 500mg one tablet for 3 days and crocin tablets. Temperature is still not coming down, temp rises to 102deg do dengue and malaria test Good evening sir.last 2days i have headache, cold and low fever. Last night and today morning I used Dolo650 tablet and citrizen tablet. But their are no result for me. Till im suffering same. So plz tell me which medicine I can use do malaria card test, widal & Dengue igg igm ns1 test Which medicine use for Malaria? What is eating in Malaria? The medicine depends upon symptoms and stage of disease Suffering from maleria since 10 days please give me prescription how do u know u have malariaand which type malaria u have I m suffering from malaria in my test malaria detect what should i do? For prescription medicines you need to go to a clinic Fever with shivering at evening only get blood checked for Malaria I have fever since last four days, I was prescribed zifi 200 and zerodol p by my doctor, but I started getting rashes, reactions, so the doctor stopped the meds, and said to have crocin only, now fourth day is over, fever comes down after having crocin then comes back again. Body ache, and headache is there, fever reaches 103, 103.8 easily every morning, have pain in my eyes also. Had zathrin 250 in the morning and at night today with crocin, my doctor suggested it on phone. What do I have? And why am I not getting better? What medication should I take? do malaria card test & widal From yesterday night onwards My body was warm and i ate a paracetamol and slept.Today morning the heat again comes and i consulted docto. he gave me some med but temp didnt went down.Now i went and got a injection.will i get the fever off because iam having an important clss tomorrow.Also my stomach is also not feeling gud. Advise-CBC, malaria antigen, widal