Migesic 200

Tolfenamic Acid is a pain relieving medicine. It is used for treatment of pain associated with acute attacks of migraine in adults. It may also be used to relief pain associated with joints and muscles. Tolfenamic Acid can be taken with food, preferably with a glass of water. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. You should keep taking the medicine even if you feel better until the doctor says it is alright to stop using it. The most common side effects of this medicine include mild indigestion, diarrhea, nausea, vomiting, stomach pain, rash, headache, and dizziness. If any of these side effects persist or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms. Before using it, you should let your doctor know if you have a history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine. Pregnant and breastfeeding mothers should consult their doctors before using the medicine. Tolfenamic Acid is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling).

• Pain relief

Tolfenamic acid, an anthranilic acid derivative, is an NSAID. It has anti-inflammatory, analgesic and antipyretic effects.

Adult Dose: Oral Acute migraine attacks Adult: 200 mg when 1st symptoms appear, may be repeated after 1-2 hr, if necessary. Mild to moderate pain Adult: 100-200 mg tid. Hepatic impairment: Severe: Avoid. Renal Dose: Renal impairment: Severe: Avoid.

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Tolfenamic Acid is to be taken with food.

Common: • Vomiting • Nausea • Indigestion • Diarrhea • Heartburn • Loss of appetite

[UNSAFE] Tolfenamic Acid may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. http://www.medicines.org.uk/emc/PIL.29405.latest.pdf It should be taken with food or milk to avoid getting an upset stomach. It can cause serious complications like stomach bleeding and kidney problems if taken for a long time. Tolfenamic Acid can raise your risk of blood clots, heart attack, or a stroke. Inform your doctor if you are pregnant or planning to conceive or breastfeeding. Inform your doctor if you have ever been diagnosed with kidney or liver problems.

Hypersensitivity to aspirin or other NSAID. Active or history of GI bleeding or ulceration, severe heart failure, history of GI bleeding or perforation related to previous NSAID therapy. Severe renal and hepatic impairment. Pregnancy (3rd trimester).

Increased rate of absorption of tolfenamic acid with metoclopramide and magnesium hydroxide. Decreased rate of absorption of tolfenamic acid with aluminium hydroxide. Increased risk of bleeding with anticoagulants and other NSAIDs. Decreased antihypertensive response to loop diuretics, ?-blockers and ACE inhibitors. Coadmin increased plasma concentrations of lithium, methotrexate and cardiac glycosides. Increased risk of nephrotoxicity with ACE inhibitors, ciclosporin, tacrolimus or diuretics.

[UNSAFE] It is unsafe to consume alcohol with Tolfenamic Acid.

[CONSULT YOUR DOCTOR] Tolfenamic Acid may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Information regarding the use of Tolfenamic Acid during breastfeeding is not available. Please consult your doctor.

[CAUTION] Tolfenamic Acid should be used with caution in patients with kidney disease. Dose adjustment of Tolfenamic Acid may be needed. Please consult your doctor. Regular monitoring of kidney function tests is advised in these patients while taking this medicine. Use of Tolfenamic Acid is not recommended in severe kidney disease patients. [CAUTION] Tolfenamic Acid should be used with caution in patients with liver disease. Dose adjustment of Tolfenamic Acid may be needed. Please consult your doctor.

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