Perinem 500

Doripenem is an antibiotic belonging to the carbapenem group that fights bacteria. It is used to treat severe infections of the skin, lungs, stomach, urinary tract, blood and brain (eg. meningitis). It works by killing the bacteria that cause these problems. Doripenem is commonly used to treat seriously ill patients admitted to the hospital. This medicine is given by drip or by direct injection into a vein, under the supervision of a healthcare professional. The dose depends on what type of infection you have, where it is in the body and how serious it is. You should have your injections at the same time each day to get the most benefit and you should keep on taking this medicine for as long as you are prescribed it, even if your symptoms quickly improve. If you stop taking it too early the infection may return or worsen. Some people may develop side effects like vomiting, headache, nausea, diarrhea, rash or local redness and swelling at the site of injection. These side effects are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or will not go away. Before starting treatment with this medicine, you should tell your doctor if you have epilepsy, liver or kidney problems or if you are allergic to any antibiotic. While using it, you may be advised blood tests to monitor your blood cell counts and kidney function. This medicine is generally regarded as safe to use in pregnancy and breastfeeding if prescribed by your doctor. Doripenem is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.

• Severe bacterial infections

Doripenem is a broad-spectrum carbapenem with potent in vitro antibacterial activity against aerobic and anaerobic gram-positive and gram-negative bacteria including Pseudomonas aeruginosa. It inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins; which in turn inhibits the final transpeptidase step of peptidoglycan synthesis in bacterial cell walls.

Adult Dose: Intravenous Complicated intra-abdominal infections Adult: 500 mg 8 hrly infused over 1 hr for 5-14 days. May switch to an appropriate oral therapy, after at least 3 days of parenteral therapy upon evidence of clinical improvement. Complicated urinary tract infections; Pyelonephritis Adult: 500 mg 8 hrly infused over 1 hr for 10 days. May switch to an appropriate oral therapy, after at least 3 days of parenteral therapy upon evidence of clinical improvement. Duration can be extended up to 14 days for patients w/ concurrent bacteraemia. Child Dose: <18 years: Safety and efficacy not established Renal Dose: Renal impairment: CrCl (ml/min) 30-50 250 mg every 8 hr by IV infusion over 1 hr 11-29 250 mg every 12 hr by IV infusion over 1 hr

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Doripenem, please consult your doctor.

Common: • Vomiting • Nausea • Injection site reactions (pain, swelling, redness)

[CONSULT YOUR DOCTOR] It is not known whether Doripenem alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Doripenem is an antibiotic that's usually only given in the hospital for serious infections. It is given by a drip into a vein (intravenous infusion) over 20 to 60 minutes. In severe cases, it may be given slowly for 3 to 4 hours by intravenous infusion. Inform your doctor if you are allergic to penicillin or if you are taking any seizure medication before starting treatment with this medication. Diarrhea may occur as a side effect. Inform your doctor if you develop severe stomach pain or if you find blood in your stools. Your doctor may monitor your liver and kidney function while you are having treatment with this medication.

Hypersensitivity; anaphylactic reactions to beta-lactams.

Increased plasma concentration w/ probenecid. May decrease plasma levels of valproic acid thus, increasing the risk of seizures.

[SAFE] Consuming alcohol with Doripenem does not cause any harmful side effects.

[SAFE IF PRESCRIBED] Doripenem is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[SAFE IF PRESCRIBED] Doripenem is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Doripenem should be used with caution in patients with kidney disease. Dose adjustment of Doripenem may be needed. Please consult your doctor. [SAFE IF PRESCRIBED] Doripenem is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Doripenem may not be needed in these patients. Please consult your doctor.

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