oshudhkosh

Perkinor5mg/5ml

Rx
Dosage form:
Syrup
Pack size:
Syrup

৳ 125/unit

Pack: ৳ 125

At a glance

Trihexyphenidyl Hydrochloride — brands, prices, indication, dosage and side effects available in Bangladesh.

Description

Trihexyphenidyl Hydrochloride is used with other medicines to treat Parkinson’s disease. It’s also used to treat severe movement side effects caused by certain drugs (drug-induced movemnet disorder). Trihexyphenidyl Hydrochloride should be taken empty stomach as it reduces the side effects of this medicine. It should be taken at the same time each day, this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember. Do not skip any doses and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to the doctor as it may result in a worsening of symptoms. Some common side effects of this medicine include nausea, vomiting, constipation, and blurred vision. It even causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Dry mouth may occur commonly while using this medicine so, try to do frequent mouth rinses, maintain good oral hygiene, and increase water intake. Avoid wearing contact lenses as it may cause dry eyes as well. It is important to inform your doctor if you suffer from glaucoma or have trouble in passing urine. Before using Trihexyphenidyl Hydrochloride, you should tell your doctor if you've ever had heart problems, problems with passing urine, liver or kidney disease. It may also affect, or be affected by, some other drugs you are using so let your doctor know what these are to be safe. Pregnant or breastfeeding mothers should consult their doctor before starting treatment with this medicine. Trihexyphenidyl Hydrochloride is an anticholinergic medication. It works by decreasing the activity of a chemical messenger (acetylcholine) in the brain. This improves muscle control and reduces stiffness in Parkinson's disease. It also improves movement disorder (restlessness, involuntary movements or muscle spasm) caused by certain other medicines.

Indications

• Parkinson's disease • Drug induced abnormal movements

Mechanism of action

Trihexyphenidyl HCl is a tertiary amine antimuscarinic which exerts a direct inhibitory effect on the parasympathetic nervous system. It also exhibits a direct spasmolytic action on smooth muscle, weak mydriatic, antisialagogue and cardiovagal blocking effects.

Dosage

Adult Dose: Oral Drug-induced extrapyramidal symptoms Adult: 5-15 mg/day PO divided q6-8hr Parkinson Disease Adult: Initially, 1 mg daily, gradually increased at intervals of 3-5 days by increments of 2 mg until 6-10 mg daily in 3-4 divided doses. Maintenance: 5-15 mg/day PO divided q6-8hr Parkinsonism Adult: 5-15 mg/day PO divided q6-8hr Elderly: May require lower doses. Child Dose: Safety and efficacy not established

Administration

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Trihexyphenidyl Hydrochloride is to be taken empty stomach.

Side effects

Common: • Dryness in mouth • Nausea • Vomiting • Constipation • Blurred vision • Dizziness • Upset stomach • Headache • Difficulty in urination • Nervousness

Precautions & warnings

[UNSAFE] Trihexyphenidyl Hydrochloride may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Trihexyphenidyl Hydrochloride can cause blurring of vision, dizziness, mild nausea, and mental confusion in some cases. This may affect your ability to drive. Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help. It may cause dry eyes. Avoid wearing contact lenses and inform your doctor if it bothers you. It may cause dizziness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you. Monitoring of intraocular pressure is required while taking this medicine, as an increase in eye pressure may cause blurry vision. Inform your doctor if you suffer from glaucoma or if you have trouble passing urine.

Contraindications

Patients with closed-angle glaucoma, chronic pulmonary disease, sick sinus syndrome, thyrotoxicosis, cardiac failure with tachycardia.

Drug interactions

Increased antimuscarinic side effects w/ phenothiazines, clozapine, antihistamines, disopyramide, nefopam and amantadine. Synergistic effect when concomitantly used w/ TCAs. Concurrent admin w/ MAOIs may cause dry mouth, blurred vision, urinary hesitancy or retention and constipation. May antagonise effect of metoclopramide and domperidone on GI function. Reduced absorption of levodopa. May antagonise effect of parasympathomimetics.

Food interactions

[UNSAFE] Trihexyphenidyl Hydrochloride may cause excessive drowsiness with alcohol.

Use in pregnancy

[CONSULT YOUR DOCTOR] Trihexyphenidyl Hydrochloride may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Use in lactation

[SAFE IF PRESCRIBED] Trihexyphenidyl Hydrochloride is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Renal / hepatic impairment

[CONSULT YOUR DOCTOR] There is limited information available on the use of Trihexyphenidyl Hydrochloride in patients with kidney disease. Please consult your doctor. Patients with kidney disease should be closely monitored by a doctor while taking this medicine. [CONSULT YOUR DOCTOR] There is limited information available on the use of Trihexyphenidyl Hydrochloride in patients with liver disease. Please consult your doctor.

Common questions

My brother is suffering withCervical dystonia and almost try Dr. Whose fee i could afford can u suggest me name or prescribe medicines tab pacitane 2 mfg bd He was on mazetol 200 BD for last 30 yes for focal seizures developed brain hge 2 yrs back due to frequent sodium depletion Mazetol was replaced by Epsolin 3 tabs daily. Also being given symdopa pacitan etc. He is on pace maker since 20 yrs. After change in medicines he is complaining of severe dryness of mouth whole body intense itching confusion cough etc. What should I do? He is diabetic on insulin. Blood sugar 148 serum sodium 137.8 Get pacitane dose reduced by ur I am suffering from neck pain last month and I am also a patient of Parkinson's disease and I am taking syndopa plus and pacitane last 1 year but not feeling well please tell me advise please sir thanks try tab tolfree 150 mg bd for a week Hello. I am suffering from sweaty hands and feet since childhood. It's OK during winter but during summer even in AC my hands are sweating like hell and when I am writing on paper, it gets smudged by my watery hands. It creates bad impression with someone I am shaking hands with. Also sweaty feet causes my feet smelly. Please help start tab pacitane 2 mg 1 bd in summer Sir, i am taking medicine sizodon 2mg and pacitane 2 mg and i have tablet which contains benzhexol hydrochloride and another tablet contains trihexyphenidyl hcl 2 mg (written on pacitane tablets on it) i am confused which is for sizdon and which is for pacitane or they both are same ? Please advise me thanks you Sizodon is resperidone- it's an antipsychotic Pacitane is trihexyphenidyl- it's an anticholinergic medicine which reduces side effect of resperidone. My mother takes syndopa 275 and pacitone together for 2 times a day. And syndopa 275 alone at night. With these she takes adcapone. She sometimes gets confused. She even cannot remember the day or things she has done earlier in the day. Should i stop pacitone or syndopa. Please suggest try stopping pacitane and see if it helps; better review with a neuro My hands are shivering while holding something. Get examined by neurologist Start tab pacitane 2 mg half tab twice a day

⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.