oshudhkosh

Phenyton30mg/5ml

Rx
Generic:
Phenytoin
Dosage form:
Suspension
Pack size:
100ml bot

৳ 1/unit

Pack: ৳ 1

At a glance

Phenytoin — brands, prices, indication, dosage and side effects available in Bangladesh.

Description

Phenytoin is a prescription medicine used to treat and prevent epilepsy (seizures). It controls seizures by decreasing the abnormal and excessive activity of the nerve cells in the brain. Phenytoin can be used alone or in combination with other medicines. It may be taken with or without food. Your doctor will decide the correct dose for you. This may increase gradually until your condition is stable. This medicine may take several weeks to work but it is important to take it regularly to get the benefit. Do not stop taking it, even if you feel fine, unless your doctor advises you to. You may have more seizures, or your bipolar disorder may get worse. The most common side effects of this medicine include skin rashes, headache, feeling or being sick, difficulty sleeping, dizziness and feeling sleepy or drowsy. Most side effects wear off, but if they bother you or do not go away, tell your doctor. There may be ways of preventing or reducing these effects. Before taking this medicine, tell your doctor if you have kidney or liver problems, meningitis or depression or suicidal thoughts. Also let your healthcare team know about all other medications you are using as some may affect, or be affected by, this medicine, including contraceptive pills. If you are pregnant or breastfeeding, Phenytoin can be taken if it is clearly needed but the dose may be adjusted. You should avoid driving or riding a bicycle if this medicine makes you drowsy or dizzy. You may need frequent blood tests to check how you are responding to this medicine. Phenytoin is an antiepileptic medication. It controls seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.

Indications

• Epilepsy/Seizures

Mechanism of action

Phenytoin acts as an anticonvulsant by increasing efflux or decreasing influx of sodium ions across cell membranes in the motor cortex during generation of nerve impulses; thus stabilising neuronal membranes and decreasing seizure activity. It acts as an antiarrhythmic by extending the effective refractory period and suppressing ventricular pacemaker automaticity, shortening action potential in the heart.

Dosage

Adult Dose: Oral Epilepsy Adult: Initially, 3-4 mg/kg daily as single dose or in divided doses. Alternatively, 150-300 mg daily increased gradually to 600 mg daily if necessary. Maintenance: 200-500 mg daily. Child Dose: Oral Control of Tonic-Clonic and Complex Partial Seizures Initial dosage Neonates: 5 mg/kg/day in 2 divided doses Child: 6 months to 16 years: 5 mg/kg/day in 2-3 divided doses Neonates (<28 days) Initial: 5-8 mg/kg/day PO divided q8-12hr Age-based maintenance dose 6 months-4 years: Usual range, 8-10 mg/kg/day PO divided two to three times daily 4-7 years: Usual range, 7.5-9 mg/kg/day PO divided two to three times daily 7-10 years: Usual range, 7-8 mg/kg/day IPO divided two to three times daily 10-16 years: Usual range, 6-7 mg/kg/day PO divided two to three times daily

Administration

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Phenytoin may be taken with or without food, but it is better to take it at a fixed time.

Side effects

Common: • Rash • Headache • Dizziness • Vomiting • Nausea • Slurred speech • Vertigo • Confusion • Nervousness • Constipation • Tremor • Altered walking

Precautions & warnings

[UNSAFE] Phenytoin may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Take your medication regularly as directed by your doctor as missing doses can trigger seizures. Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you. Some healthy tips to prevent seizures: It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you. It may increase blood sugar levels. Inform your doctor if you are taking any medicines to treat diabetes. It may cause swollen gum (gum hypertrophy), hence take care of oral or dental hygiene. Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts. Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.

Contraindications

Pregnancy.

Drug interactions

Effects with other sedative drugs or ethanol may be potentiated. Enhances toxic effects of paracetamol, lithium. Increased risk of osteomalacia with acetazolamide. Decreased serum levels/effects with acyclovir, antineoplastics, benzodiazeines, ciprofloxacin, CYP2C9 inducers (e.g. carbamazepine), CYP2C19 inducers (e.g. rifampin), folic acid, vigabatrin. Increased serum concentrations with allopurinol, capecitabine, cimetidine, CYP2C9 inhibitors (e.g. fluconazole), CYP2C19 inhibitors (e.g. delavirdine), disulfiram, methylphenidate, metronidazole, omeprazole, SSRI, trazodone, trimethoprim. Increases metabolism of antiarrhythmics, anticonvulsants, antipsychotics, beta-blockers, calcium channel blockers, chloramphenicol, corticosteroids, doxycycline, oestrogens, HMG-CoA reductase inhibitors, methadone, theophylline, TCAs. Decreases levels/effects of clozapine, ciclosporin, tacrolimus, CYP2B6 substrates (e.g. bupropion, selegiline), CYP2C8 substrates (e.g. amiodarone), CYP2C9 substrates (e.g. celecoxib), CYP2C19 substrates (e.g. citalopram), CYP3A4 substrates (e.g. benzodiazepines), digoxin, itraconazole, levodopa, neuromuscular-blocking agents, thyroid hormones, topiramate. Increases levels/effect of dopamine, ticlopidine. Valproic acid may displace phenytoin from binding sites; and affect phenytoin serum concentrations. Transiently increases the hypothrombinaemia response to warfarin initially, followed by an inhibition of the response. Potentially Fatal: Enhances the hypotensive properties of dopamine and the cardiac depressant properties of lidocaine.

Food interactions

[UNSAFE] It is unsafe to consume alcohol with Phenytoin.

Use in pregnancy

[CONSULT YOUR DOCTOR] Phenytoin is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Use in lactation

[SAFE IF PRESCRIBED] Phenytoin is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby. Please consult your doctor.

Renal / hepatic impairment

[CAUTION] Phenytoin should be used with caution in patients with kidney disease. Dose adjustment of Phenytoin may be needed. Please consult your doctor. [CAUTION] Phenytoin should be used with caution in patients with liver disease. Dose adjustment of Phenytoin may be needed. Please consult your doctor.

Common questions

Want discontinued eptoin tablet Father had brain stroke so doctor is giving eptoin tablet 300 mg so I want ask that can tablet can remove or dose decreased ? wil depend on any recent seizures he had; and type of stroke; pls show 2 neuro My said uncle is taking Epilan 100mg for epileptic reason. But this medicine is not easily available at his place. Can he take Epicom 100mg as its substitute? Please reply. Or any other available substitute? TAB. EPTOIN / TAB. CELETOIN/ TAB. PHENYTOIN. I have alexia due to a clot in my head . I used to have fits when the clot was there but now it has stopped . I take 200mg of eptoib and 1000 mb of levepsy. But from last 2-3days I have ataxia. What should I change in my pills? Sorry for the mistake, it&#x27;s eptoin. Stop eptoin immediately Show to neurologist My child suffring seizures though she is taking oxetal 150 mg.1--- half with eptoin 2.5 ml.what is reason? two reasons- less dose or other diagnosis I am taking eptoin 100 mg tablets daily three how to leave it Eptoin is prescribed for treatment of epilepsy/fits. Based on your clinical history, your doctor plans the type of medicine and it&#x27;s dose and duration. For first episode of epileptic fit the usual maintenance phase is 3years of asymptomatic period, after which medicines can be gradually tapered. But treatment may need to continue longer depending on severity and frequency of episodes. To take any decision to change medication or stop them, several factors have to be taken in account for which regular follow up with your psychiatrist or neurologist is important. For second opinion, seek a proper consultation with another psychiatrist or neurologist and take along your previous prescriptions. Sir last 2 year I am suffering from epilespy. I am on eptoin 300 er from 2 feb 2014. How long medicinal will contine. From 2014 til now there is no problem or stock The usual treatment for epilepsy lasts for 3 years of seizure free interval. Suffering 4M Epilepsy Take Medicine Gardenal 60mg 1.5 tab. & Eptoin 100 Mg 3 tab 4 Last 5 or 6 years what is the side effects And how many time to take medicine Medications can be stopped after cessation of seizure of episode for continuous two years. And two consecutive EEG being normal space out of 1 year.Side effects you can check from our app.

⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.