Prosulf10mg/ml

Protamine Sulfate is a medicine which is used in the treatment of heparin overdose. It neutralizes the anti-blood clotting effect of heparin and stops excessive bleeding. Protamine Sulfate is generally administered by a healthcare professional. You should not self administer this medicine. Inform your doctor if you have undergone heart surgery, have had a vasectomy, have diabetes, have received protamine insulin, or allergic to fish. Using of Protamine Sulfate can cause few side effects such as decreasing your blood pressure, slow heart rate, or reactions at the site of injection. It is important to monitor the clotting levels if you are receiving multiple doses or prolonged administration of protamine. Protamine Sulfate is used to counteract the anticoagulant effect of heparin and is used to stop bleeding in patients caused by heparin.

• Heparin overdose

Protamine sulfate is prepared from the sperm or mature testes of salmon or related species and is composed of arginine, proline, serine and valine. It combines w/ strongly acidic heparin to form a stable complex, neutralising the anticoagulant activity of both drugs.

Adult Dose: Heparin Neutralization 1-1.5 mg per 100 USP units of heparin; not to exceed 50 mg Monitor APTT 5-15 min after dose then in 2-8 hr In accidental overdoses of heparin, consider t1/2 heparin 60-90 min In setting without bleeding complications, consider observation, rather than reversal of anticoagulation with protamine (avoids ADR's) Complex of protamine and heparin may degrade over time requiring further doses Dalteparin or Tinzaparin Overdose 1 mg protamine for 100 units dalteparin or tinzaparin; if PTT prolonged 4hr after protamine overdose administer 0.5 mg per 100 units of dalteparin or tinzaparin Enoxaparin Overdose 1 mg per mg enoxaparin (if enoxaparin overdose given within 8 hr); if >8 hr of overdose or bleeding continues after 4 hr after first dose, give 0.5 mg protamine per mg enoxaparin Time Elapsed Since Heparin Dose Dose of protamine (mg) to neutralize 100 units of heparin 2 hr: 0.25-0.375 mg/100 units of heparin

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Protamine Sulfate, please consult your doctor.

Common: • Hypersensitivity • Decreased blood pressure • Slow heart rate

[SAFE] Protamine Sulfate does not usually affect your ability to drive.

Hypersensitivity

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Protamine Sulfate. Please consult your doctor.

[CONSULT YOUR DOCTOR] Protamine Sulfate may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Protamine Sulfate is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[SAFE IF PRESCRIBED] Protamine Sulfate is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Protamine Sulfate may not be needed in these patients. Please consult your doctor. [SAFE IF PRESCRIBED] Protamine Sulfate is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Protamine Sulfate may not be needed in these patients. Please consult your doctor.

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