Pulmidone 801

Pirfenidone is a prescription medicine used in the treatment of idiopathic pulmonary fibrosis. It reduces scarring and swelling in the lungs and helps to breathe better. It may be taken with food. But, It is better to take it at the same time every day to get the most benefits. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. The most common side effects of this medicine include insomnia, headache, and dizziness. To overcome dizziness, avoid driving or attention-seeking activity. Some people may experience weight loss, hence monitor your weight regularly or ask for doctor consultation. Some side effects, which means you must inform your doctor include abdominal pain, loss of appetite, darkened urine or yellowing of the eyes. Your doctor may perform a liver function test while on treatment. Before taking this medicine, let your doctor know if you have liver or kidney disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. It makes your skin sun-sensitive, wear protective clothing or apply sunscreen while in direct contact with sun. Inform your doctor if you are pregnant or breastfeeding. Pirfenidone is an antifibrotic medication. It works by reducing fibrosis (scarring) and swelling in the lungs. This makes breathing easier.

• Idiopathic pulmonary fibrosis

Precise mechanism by which pirfenidone may work in pulmonary fibrosis has not been established Inhibits transforming growth factor (TGF)-beta, a chemical mediator that controls many cell functions including proliferation and differentiation Also inhibits the synthesis of TNF-alpha, a cytokine that is known to have an active role in inflammation

Adult Dose: Idiopathic Pulmonary Fibrosis Initial dose titration Days 1-7: 267 mg (1 capsule) PO TID Days 8-14: 534 mg (2 capsules) PO TID Day 15 and thereafter: 801 mg (3 capsules) PO TID Maintenance dose 801 mg (3 capsules) PO TID with food Not to exceed 2403 mg/day (9 capsules/day) Hepatic impairment Mild-to-moderate (Child Pugh A or B): Use caution; monitor and consider dosage modification or discontinuation as needed Severe (Child Pugh C): Not recommended (not studied) Child Dose: Safety and efficacy not established Renal Dose: Renal impairment Mild, moderate, or severe: Use caution; monitor and consider dosage modification or discontinuation as needed ESRD requiring dialysis: No recommended (not studied)

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pirfenidone is to be taken with food.

Common: • Insomnia (difficulty in sleeping) • Headache • Dizziness • Tiredness • Sinus inflammation • Loss of appetite • Upper respiratory tract infection • Weight loss

[UNSAFE] Pirfenidone may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Pirfenidone reduces scarring and swelling in the lungs, and helps you breathe better. It is best to take this medicine with food and at the same time each day. This medication may make you more sensitive to sun. Use sunscreen and wear protective clothing when outdoors. Stop smoking during treatment with Pirfenidone as it can reduce the effect of the treatment. It may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you. It may cause weight loss. Monitor your weight regularly. Your doctor may check your liver function regularly. Inform your doctor if you develop abdominal pain, loss of appetite, darkened urine or yellowing of the eyes or skin (jaundice).

Hypersensitivity. History of angioedema. Severe hepatic & renal impairment or end stage liver & renal disease. Concomitant use w/ fluvoxamine.

Inhibition of CYP1A2 w/ concomitant grapefruit juice. Increased exposure w/ fluvoxamine & other strong & selective CYP1A2 inhibitors, ciprofloxacin, amiodarone, propafenone. Potential to induce hepatic enzyme production by smoking. Lowered plasma levels w/ omeprazole, rifampicin.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Pirfenidone. Please consult your doctor.

[CONSULT YOUR DOCTOR] Pirfenidone may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Information regarding the use of Pirfenidone during breastfeeding is not available. Please consult your doctor.

[CAUTION] Pirfenidone should be used with caution in patients with kidney disease. Dose adjustment of Pirfenidone may be needed. Please consult your doctor. Use of Pirfenidone is not recommended with severe kidney disease and dialysis patients. [CAUTION] Pirfenidone should be used with caution in patients with liver disease. Dose adjustment of Pirfenidone may be needed. Please consult your doctor. Use of Pirfenidone is not recommended in patients with severe liver disease.

Can idiopathic pulmonary fibrosis be cured? I would like to suggest you that please consult with your nearest homeopathy doctor because your case require detail case taking. My mother is suffering from Interstitial Lungs disease since 4 yrs.She is on home oxygen since 3 yrs from then for atleast 14-16 hrs.Currently she is getting treatment from AIIMS,New Delhi and the medecines given are as under:- Pirfenidone (600mg-Thrice a day) Sildenafil (25mg-Thrice a day) Tab Uprise D3 for calcium-60000 units (Once a month) Tab DDR60-Once a day. The treatment has been for exactly 1 yrs and 3 months from now but the disease is still on a progressive mode.She is not improving.My family is very worried. Please help out with proper treatment for this disease.This disease is also known as Idiopathic Pulmonary Fibrosis (IPF). Best Regards Mayur PATIENT Case has to be correlated with Ayurveda, for this case has to be seen in person before starting the treatment as correlation of case with Ayurveda need to be done My mother is suffering from Interstitial Lungs disease since 4 yrs.She is on home oxygen since 3 yrs from then for atleast 14-16 hrs.Currently she is getting treatment from AIIMS,New Delhi and the medecines given are as under:- Pirfenidone (600mg-Thrice a day) Sildenafil (25mg-Thrice a day) Tab Uprise D3 for calcium-60000 units (Once a month) Tab DDR60-Once a day. The treatment has been for exactly 1 yrs and 3 months from now but the disease is still on a progressive mode.She is not improving.My family is very worried. Please help out with proper treatment for this disease.This disease is also known as Idiopathic Pulmonary Fibrosis (IPF). Best Regards Mayur PATIENT Please consult chest physician Hiii my wife having hurt patient ( pulmonary hypertension ) she's taking pulmonext 5mg tablet but this tablet is very costly for me of Rs. 1450/- 10tab. I want to know any another tablet available in same drugs with low price This can't be decided online Your doctor is the best judge about your patients pulmonary hypertension What is reason for the psoriasis? mostly idiopathic sometimes some Medicines may be responsible for its exacerbation Lung fibrosis ptacent pulmonology Treatment for Lungs Fibrosis (Pulmonogist) I would like to suggest you that please consult with your nearest homeopathy doctor because your case requires detail case taking. Dear sir im taking morease 135 mg tab for ibs problem last 6 years now the days last one month im suffering from allergic chest nd cough with uneasy breathing problem sir please kindlly guide me is that problem are side effects of morease tablet im stopped taking tablets from today.plss help me what can I do Please get chest X Ray ECG and pulmonary function test to know the problem Good after noon sir sir my problem is that i have cough nd phelgum problem since last 2 year and i am a daily smocker sir plz guide me what can i do plz Meet good pulmonary medicine specialist