oshudhkosh

Sofoxen400mg

Rx
Generic:
Sofosbuvir
Dosage form:
Tablet
Pack size:
Box (28 Tablet)

৳ 600/unit

Pack: ৳ 16,800

At a glance

Sofosbuvir — brands, prices, indication, dosage and side effects available in Bangladesh.

Description

Sofosbuvir is an antiviral medication. It is used along with other medications for the treatment of chronic hepatitis C virus (HCV) infection. It works by lowering a load of hepatitis C virus in the body and removing the virus from the blood over a period of time. Sofosbuvir should be taken in the dose and duration as advised by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. It should be taken with food, preferably at a fixed time. If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. It has fewer side effects as compared to other similar medicines, like fatigue, headache, nausea, insomnia (difficulty sleeping) and anemia (low red blood cell count). Inform your doctor if these side effects persist for a longer duration. Please consult your doctor if you are pregnant, planning to conceive or breastfeeding. Sofosbuvir is an antiviral medication. It works by lowering a load of hepatitis C virus in the body and removing the virus from the blood over a period of time.

Indications

• Chronic hepatitis C virus (HCV) infection

Mechanism of action

Nucleotide prodrug that undergoes metabolism to the active uridine analog triphosphate, an inhibitor of HCV NS5B RNA-dependent polymerase; its inhibition in turn suppresses viral replication .

Dosage

Adult Dose: Oral Chronic Hepatitis C One 400 mg tablet taken once daily with or without food - Should be used in combination with Ribavirin or in combination with Pegylated Interferon and Ribavirin for the treatment of CHC. Recommended combination therapy: (HCV Mono-infected and HCV/HIV-1 Co-infected ) Genotype 1 or 4 : Sofosbuvir + Peginterferon alfa + Ribavirin for 12 weeks Genotype 2: Sofosbuvir + Ribavirin for 12 weeks Genotype 3: Sofosbuvir + Ribavirin for 24 weeks - Sofosbuvir in combination with Ribavirin for 24 weeks can be considered for CHC patients with genotype 1 infection who are Interferon ineligible - Should be used in combination with Ribavirin for treatment of CHC in patients with hepatocellular carcinoma awaiting liver transplantation for up to 48 weeks or until liver transplantation whichever occurs first - A dose recommendation cannot be made for patients with severe renal impairment or end stage renal disease Child Dose: Safety and efficacy not established

Administration

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sofosbuvir is to be taken with food.

Missed dose

If you miss a dose of Sofosbuvir, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Side effects

Common: • Fatigue • Nausea • Headache • Insomnia (difficulty in sleeping) • Anemia (low number of red blood cells)

Precautions & warnings

[UNSAFE] Sofosbuvir may cause side effects which could affect your ability to drive. Sofosbuvir, when taken together with other medicines for the treatment of hepatitis c infection, may produce dizziness, blurred vision and this may affect your ability to drive. Sofosbuvir is used along with other medications for the treatment of chronic hepatitis C virus (HCV) infection. Do not skip any doses and finish the full course of treatment even if you feel better. It has fewer side effects compared to other similar medications. Take it with food, preferably at the same time everyday. You will usually need to take this medicine every day for either 12 or 24 weeks. It may cause fatigue, dizziness, and blurred vision. Don't drive or do anything requiring concentration until you know how it affects you. Your doctor may monitor your liver function and the amount of hepatitis C virus in your body regularly. Do not stop taking Sofosbuvir without your doctor's advice.

Contraindications

When Sofosbivur is used in combination with Ribavirin or Peginterferon alfa/Ribavirin, the contraindications applicable to those agents are applicable to combination therapies. Sofosbuvir combination treatment with Ribavirin or Peginterferon alfa/Ribavirin is contraindicated in women who are pregnant or may become pregnant and men whose female partners are pregnant, because of the risks for birth defects and fetal death associated with Ribavirin.

Drug interactions

Reduced therapeutic effect w/ drugs that are potent P-gp inducers in the intestine (eg rifampicin, St. John's wort, carbamazepine & phenytoin), modafinil, phenobarb/oxcarbazepine, rifabutin/rifapentine. P-gp &/or BCRP inhibitors. May result in serious symptomatic bradycardia when co-administered w/ amiodarone in combination w/ another direct acting antiviral.

Food interactions

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Sofosbuvir. Please consult your doctor.

Use in pregnancy

[SAFE IF PRESCRIBED] Sofosbuvir is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Use in lactation

[SAFE IF PRESCRIBED] Sofosbuvir is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Renal / hepatic impairment

[CAUTION] Sofosbuvir should be used with caution in patients with severe kidney disease. Dose adjustment of Sofosbuvir may be needed. Please consult your doctor. Limited information is available on use of Sofosbuvir in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease. [SAFE IF PRESCRIBED] Sofosbuvir is safe to use in patients with liver disease. No dose adjustment of Sofosbuvir is recommended.

Common questions

How to treatment of HEPATITIS C VIRUS https://www.1mg.com/otc/himalaya-liv.-52-ds-tablet-otc135545One ?one tablet morning & evening after taking food , use at least 1-2 monthsUse this medicine along with your treatment I am affected from hepatitis c virus diagnosed with confirmed genotype. Meanwhile i am pregnant will hepatitis virus pass on my baby. Or i should abort Your reports are of february with no ongoin liver damage. You havnt got the quantitative analysis. Most probably you wont need to abort. But be in constant follow up of good gastroenterologist near you. How to get rid of Hepatitis C virus present inside the body which is still nonreactive ? Consult a Gastro enterologist Have chronic infection with semun c/s Ecoli Please elaborate your symptoms, history, treatment and investigations done. What is the GTT, HCB, tests in pregnancy ? These tests help to know chicness of diabetes in a pregnant mother and HCV is a hepatitis test. Suffering from Hepatitis B virus from last one week. Please suggest me. Pls consult a gastroenterologist Hepatitis c , drug suggest me salt name , popular brand in india Hello doctor , will you suggest me drug for hepatitis c you need to be examined in clinic before any opinion can be given Suffering from liver cancer and hepatitis c Dear sir homeopathy can be taken as Add-on therapy in your case which shall improve your quality of life and decrease the progression of disease. You can visit a homeopath for detailed discussion and treatment

⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.