৳ 15/unit
Pack: ৳ 150
৳ 15/unit
Pack: ৳ 150
At a glance
Moxonidine is a centrally-acting antihypertensive used for high blood pressure. It stimulates central imidazoline receptors in the brainstem to reduce sympathetic tone and relax blood vessels, lowering blood pressure.
Indications
- Hypertension (high blood pressure)
Pharmacology
Moxonidine stimulates imidazoline receptors (I1) in the brainstem to reduce sympathetic nerve activity, decreasing systemic vascular resistance and arterial blood pressure. Low affinity for alpha2-adrenoceptors results in fewer sedation and dry mouth side effects.
Dosage
Adult Dose (Oral):
- Initial: 200 mcg in the morning
- After 3 weeks if needed: 400 mcg (single or divided dose)
- After further 3 weeks if needed: Up to 600 mcg (divided dose)
- Maximum dose: 600 mcg/day
Renal Dose:
- CrCl 30-60: Single dose not to exceed 200 mcg; max 400 mcg/day
- CrCl <30: Avoid use
Side effects
Common Side Effects:
- Dry mouth
- Headache
- Dizziness
- Somnolence
- Weakness
- Nausea, vomiting
- Diarrhea
- Back pain
- Insomnia
- Vertigo
- Rash
Use in pregnancy
Use in Pregnancy: Moxonidine may be unsafe during pregnancy (Category B3); animal studies show evidence of fetal harm. Use only if clearly needed.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Caution when driving or doing activities requiring concentration (may cause drowsiness and dizziness)
- Avoid alcohol (excessive drowsiness)
- May cause orthostatic hypotension; rise slowly
- Rebound hypertension may occur if stopped abruptly with beta-blockers; stop beta-blocker first
- Caution in renal impairment; dose adjustment needed
- Caution in severe liver disease
Overdose effects
Overdose: Hypotension, bradycardia, dry mouth, somnolence, nausea; symptomatic treatment.
Storage conditions
Store below 25°C; protect from light and moisture; keep out of reach of children.