Conjugated Oestrogens

Conjugated Oestrogens is a female sex hormone (estrogen). It is a part of female hormonal replacement therapy which helps in treating estrogen deficiency symptoms like hot flushes (red and warm face) and vaginal dryness. Conjugated Oestrogens is also used to prevent osteoporosis (thinning and weakening of bone) in postmenopausal women, who are at high risk of fractures and can not take other preventive medicines for osteoporosis. It can be taken with or without food, but remember to take it at a fixed time each day for better efficacy. The dose and duration will be decided by your doctor so that you get the right amount to control your symptoms.

Conjugated Oestrogens is a mixture of estrogens (female sex hormone). In women who are undergoing or have attained menopause, it prevents symptoms such as hot flushes, night sweats and mood swings. It also prevents the bones from becoming porous and fragile (osteoporosis).

• Menopausal Vasomotor Symptoms (hot flashes)
• Atrophic Vaginitis/Kraurosis Vulvae
• Female Hypogonadism
• Osteoporosis Prophylaxis
• Prostate Cancer (Palliation)
• Breast Cancer (Palliation)
• Abnormal Uterine Bleeding

Estrogens modulate pituitary secretion of gonadotropins, luteinising hormones and follicle-stimulating hormones through negative feedback mechanism, thus reducing elevated levels of hormones in postmenopausal women during estrogen replacement therapy.

Estrogens modulate pituitary secretion of gonadotropins, luteinising hormones and follicle-stimulating hormones through negative feedback mechanism, thus reducing elevated levels of hormones in postmenopausal women during estrogen replacement therapy.

Adult Dose (Oral):

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Conjugated Oestrogens may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Conjugated Oestrogens, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common Side Effects:

• Bloating
• Breast pain
• Hair loss
• Headache
• Irregular vaginal bleeding
• Nausea
• Stomach cramp
• Vomiting
• Vaginal discharge changes

Serious Side Effects: Breast cancer, blood clots (DVT, PE), stroke, heart attack, gallbladder disease, dementia.

• You have been prescribed Conjugated Oestrogens as a part of hormone replacement therapy to relieve symptoms of menopause.
• Take it at the same time everyday to help you remember to take it.
• Inform your doctor if you experience any unusual vaginal bleeding or spotting, abnormal vaginal discharge or vaginal discomfort.
• It may increase the risk of breast cancer. Have regular breast examinations.
• Stop taking this medicine and inform your doctor immediately if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, or changes in vision (could be symptoms of a blood clot).
• Contraindicated during pregnancy.

• Severe liver impairment
• Breast carcinoma
• Thromboembolic disorders
• Cardiovascular disease
• Undiagnosed vaginal bleeding
• Estrogen-dependent neoplasms
• Hypersensitivity
• Pregnancy

Rifampicin, barbiturates increase rate of metabolism. May reduce the efficacy of anticoagulants.

[CAUTION] Caution is advised when consuming alcohol with Conjugated Oestrogens. Please consult your doctor.

[CONSULT YOUR DOCTOR] Conjugated Oestrogens is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. Pregnancy Category X.

[SAFE IF PRESCRIBED] Conjugated Oestrogens is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Limited information is available regarding use in children.

Limited information is available regarding dose adjustment for elderly patients.

[UNSAFE] Conjugated Oestrogens is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor.

[UNSAFE] Conjugated Oestrogens is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.

Conjugated Oestrogens overdose symptoms include nausea, vomiting, breast tenderness, dizziness, abdominal pain, and fatigue. Withdrawal bleeding may occur. Treatment is symptomatic and supportive.

Store in a cool and dry place, away from light and out of reach of children.

Conjugated Oestrogens