Dobixin 102mg/ml

Doxorubicin Hydrochloride is used in the treatment of some kinds of cancer. It is also used in the treatment of breast cancer, where there is an increased cardiac risk. It can be used on its own, or sometimes given together with certain other medicines as part of combination chemotherapy. Doxorubicin Hydrochloride can be used in both adults and children. It is given as injection into vein with extreme caution by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. It makes contraceptive pills less effective, so it advised to use reliable contraception during and after 6 months of the treatment. The most common side effects of this medicine include nausea, vomiting, rash, weakness, low blood platelets. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. It is very strong medicine and some people may develop serious side effects while taking it. This medicine may lead to problems with your blood, liver or heart. Your doctor will advise you regular blood tests to check for these. Before taking this medicine, let your doctor know if you have liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Tell your doctor if you are pregnant or breastfeeding. Doxorubicin Hydrochloride is an anti-cancer medication. It works by damaging the genetic material (DNA) of the cancer cells and stops their growth and multiplication.

• Cancer

Doxorubicin is a cytotoxic anthracycline antibiotic. The cytotoxic action results from its binding to DNA and inhibition of nucleic acid synthesis. Doxorubicin has been shown to produce regression in a variety of disseminated malignancies.

Adult Dose: Intravenous As Doxorubicin liposomal Kaposi's Sarcoma Indicated for AIDS-related Kaposi’s sarcoma in patients after failure of prior systemic chemotherapy or intolerance to such therapy 20 mg/m² IV q3Weeks Ovarian Cancer Indicated for ovarian cancer in patients whose disease has progressed or recurred after platinum-based chemotherapy 50 mg/m² IV q4Weeks x 4 courses minimum Multiple Myeloma Indicated in combination with bortezomib for multiple myeloma in patients who have not previously received bortezomib and have received at least 1 prior therapy 30 mg/m² IV on day 4 following bortezomib 1.3 mg/m² on days 1, 4, 8 & 11 q3Weeks Metastatic breast cancer Adult: 60-75 mg/m2 BSA once every 3 wk in combination with cyclophosphamide given as an infusion over 1 hr diluted in 0.9% sodium chloride or 5% glucose. Irrigation Local malignant neoplasms in the bladder Adult: 50 ml of a 1 mg/ml solution instilled into the bladder for 1 hr once a mth. Hepatic Impairment Serum bilirubin <1.2 mg/dL: Dose adjustment not necessary Serum bilirubin 1.2-3 mg/dL [20.5-51.3 micromoles/L]: Give 50% dose Serum bilirubin: 3.1-5 mg/dL [53-85.5 micromoles/L]: Give 25% dose Severe hepatic impairment: Contraindicated Child Dose: Safety and efficacy not established Renal Dose: Renal Impairment Dose adjustment not necessary

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Common: • Nausea • Vomiting • Rash • Weakness • Low blood platelets • Fatigue • Fever • Decreased white blood cell count (neutrophils) • Loss of appetite • Anemia (low number of red blood cells) • Constipation • Stomatitis (Inflammation of the mouth) • Diarrhea • Painful blisters on hands and feet

[UNSAFE] Doxorubicin Hydrochloride may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Doxorubicin Hydrochloride helps treat cancer of the breast, blood, and ovaries. It is given through a drip into a vein (intravenous infusion) by a doctor or nurse. It may make you feel tired or sleepy. Do not drive or do anything that requires mental focus until you know how it affects you. Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for 6 months after stopping treatment. Inform your doctor if you notice sores, discolouration or any discomfort in your mouth. Your doctor may get regular blood tests done to monitor your blood cells, liver, and heart function during treatment with this medicine. Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.

Cardiac disease, neonates, pregnancy and lactation, prior irradiation to mediastinum. IM/SC admin. Severe myelosuppression due to previous treatment with antitumour agents or radiotherapy.

Doxorubicin interacts with a number of other drugs e.g. antibiotics (aminoglycosides), steroids, aminophylline and propranolol. Potentially Fatal: Cholestasis induced by mercaptopurine may be potentiated by concurrent administration of the drug. Toxicity may be increased if streptozocin is given concurrently.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Doxorubicin Hydrochloride. Please consult your doctor.

[CONSULT YOUR DOCTOR] Doxorubicin Hydrochloride is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[CONSULT YOUR DOCTOR] Information regarding the use of Doxorubicin Hydrochloride during breastfeeding is not available. Please consult your doctor.

[SAFE IF PRESCRIBED] Doxorubicin Hydrochloride is safe to use in patients with kidney disease. No dose adjustment of Doxorubicin Hydrochloride is recommended. Caution is advised in patients with severe kidney disease as the information available is limited for use of this medicine in these patients. [CAUTION] Doxorubicin Hydrochloride should be used with caution in patients with liver disease. Dose adjustment of Doxorubicin Hydrochloride may be needed. Please consult your doctor. Use of Doxorubicin Hydrochloride is not recommended in patients with severe liver disease.

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