Triprim DS800mg+160mg
Rx- Company:
- Supreme Pharmaceuticals Ltd.
- Dosage form:
- Tablet
- Pack size:
- Tablet
৳ 2/unit
Pack: ৳ 2
At a glance
Sulphamethoxazole + Trimethoprim (Co-trimoxazole) — brands, prices, indication, dosage and side effects available in Bangladesh.
Description
Sulphamethoxazole + Trimethoprim (Co-trimoxazole) is a combination medicine that is used to treat various types of bacterial infections such as pneumonia, bronchitis, infections of urinary tract, ear, and abdomen. It prevents the growth of microorganisms to cure the infection. Sulphamethoxazole + Trimethoprim (Co-trimoxazole) is a prescription medicine that is advised to be taken as suggested by the doctor. It should be taken with food and it must be taken at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as an overdose of it may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The treatment must be completed even if you feel better to ensure a complete recovery. Sulphamethoxazole + Trimethoprim (Co-trimoxazole) may lead to some side effects such as nausea, vomiting, stomach pain, loss of appetite, headache, etc. To overcome any such side effects, it is advised to eat a healthy balanced diet and drink plenty of fluid. If any of the side effects get aggravated, contact your doctor immediately. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must consult your doctor immediately. Before taking this medicine, you should tell your doctor if you have any problems with your liver or kidneys. Also, tell your doctor if you are on any medication for any health condition. Pregnant or breastfeeding women should also consult with the doctors before taking it. Avoid drinking alcohol as it can cause excessive dizziness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. If you are a known allergic to the medicine, you must refrain from using this medicine and consult your doctor. It is advised to take proper rest during the course of treatment for the medicine to work effectively. Sulphamethoxazole + Trimethoprim (Co-trimoxazole) is a combination of two antibiotics: Sulfamethoxazole and Trimethoprim. These antibiotics work by preventing the bacteria from producing folic acid, a nutrient required for bacterial multiplication. Together, they treat your infection effectively.
Indications
• Bacterial infections
Mechanism of action
Co-trimoxazole exhibits the synergistic actions of its components (sulfamethoxazole and trimethoprim) by 10-fold. Sulfamethoxazole inhibits dihydrofolic acid formation from PABA, thus interfering with synthesis and growth of bacterial folic acid. Trimethoprim inhibits enzymes folic acid pathway, preventing the reaction of the dihydrolic acid to tetrahydrofolate. Co-trimoxazole possesses bactericidal effects against E coli, Klebsiella spp, Enterobacter spp, M morganii, P mirabilis, P vulgaris, H influenzae, Strep pneumoniae, Pneumocystis (carinii) jiroveci, Cyclospora spp.
Dosage
Adult Dose: Oral Acute exacerbations of chronic bronchitis ; Acute otitis media; Urinary tract infections, GI infections; Resp and urinary tract infections; Susceptible infections Adult: Tablet : 2 tablet of 480mg twice daily. In severe cases, 3 times/day. DS Tablet : 1 tablet (960mg) twice daily. Suspension : 1-2 teaspoonful twice daily. Pneumocystis (carinii) jiroveci pneumonia Up to 120 mg/kg/day in 2-4 divided doses for 14-21 days. Prophylaxis of Pneumocystis (carinii) jiroveci pneumonia 960 mg once daily for 7 days; 960 mg once daily 3 times wkly on alternate days; or 960 mg bid 3 times wkly on alternate days. Infection prophylaxis in AIDS patients 960 mg/day. Hepatic impairment: Severe: Contraindicated. Child Dose: Child: Oral 8–10 mg TMP/kg/day q12h 2 mg TMP/kg/day for UTI prophylaxis q24h 15–20 mg TMP/kg/day for Pneumocystis (carinii) jiroveci pneumonia treatment q6–8h 150 mg TMP/m2/day, OR 5 mg TMP/kg/day for Pneumocystis (carinii) jiroveci pneumonia prophylaxis q12h, 3 times a week OR q24h Renal Dose: Renal impairment: CrCl (ml/min) Dosage Recommendation <15 Not recommended. 15-30 Half the standard dose.
Administration
Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Sulphamethoxazole + Trimethoprim (Co-trimoxazole) is to be taken with food.
Side effects
Common: • Nausea • Vomiting • Skin rash • Allergic reaction
Precautions & warnings
[CONSULT YOUR DOCTOR] It is not known whether Sulphamethoxazole + Trimethoprim (Co-trimoxazole) alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. You have been prescribed Sulphamethoxazole + Trimethoprim (Co-trimoxazole) for the treatment of many types of bacterial infections. Finish the prescribed course of Sulphamethoxazole + Trimethoprim (Co-trimoxazole), even if you start to feel better. Stopping it early may make the infection come back and harder to treat. Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools. Stop taking Sulphamethoxazole + Trimethoprim (Co-trimoxazole) and inform your doctor if you develop skin rash/blisters or other unexplained skin reaction while taking Sulphamethoxazole + Trimethoprim (Co-trimoxazole). In case of long-term use, have regular monthly blood tests to monitor your blood cells as suggested by your doctor.
Contraindications
Known hypersensitivity to trimethoprim or sulfonamides; severe hepatic failure or marked liver parenchymal damage, jaundice; serious haematological disorders and porphyria; severe renal insufficiency where repeated measurements of the plasma concentration cannot be performed; history of drug-induced immune thrombocytopenia w/ use of trimethoprim and/or sulfonamides; megaloblastic anaemia due to folate deficiency. Neonates 4 wk. Treatment of Group A β-haemolytic streptococcia. Pregnancy, esp in the period prior to birth. Concomitant use w/ clozapine. Concomitant use w/ leucovorin for the treatment of P. jiroveci in HIV positive patients.
Drug interactions
Reduced ciclosporin concentrations in blood when used concurrently. Increases toxicity of methotrexate. Inhibits phenytoin clearance. Potentiates warfarin and oral hypoglycaemics. Potentially Fatal: Co-admin with pyrimethamine causes megaloblastic anaemia. Enhancement of renal damage by ciclosporin.
Food interactions
[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Sulphamethoxazole + Trimethoprim (Co-trimoxazole). Please consult your doctor.
Use in pregnancy
[CONSULT YOUR DOCTOR] Sulphamethoxazole + Trimethoprim (Co-trimoxazole) is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Use in lactation
[SAFE IF PRESCRIBED] Sulphamethoxazole + Trimethoprim (Co-trimoxazole) is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby. There may be a possibility of skin rash in the baby.
Renal / hepatic impairment
[CAUTION] Sulphamethoxazole + Trimethoprim (Co-trimoxazole) should be used with caution in patients with kidney disease. Dose adjustment of Sulphamethoxazole + Trimethoprim (Co-trimoxazole) may be needed. Please consult your doctor. Use of Sulphamethoxazole + Trimethoprim (Co-trimoxazole) is not recommended in patients with severe kidney disease. [CAUTION] Sulphamethoxazole + Trimethoprim (Co-trimoxazole) should be used with caution in patients with liver disease. Dose adjustment of Sulphamethoxazole + Trimethoprim (Co-trimoxazole) may be needed. Please consult your doctor. Use of Sulphamethoxazole + Trimethoprim (Co-trimoxazole) is not recommended in patients with the severe liver disease.
Common questions
My son is suffering from cold and fever. I want to give him septran so please advise what would be the appropriate dosage of septran Septran is prescription drug and antibiotics with many side effectsThere are many underlying causes of your symptoms. Specific treatment can not be given unless we establish exact underlying cause. Please consult Pediatrician. will take detail history and will examine your child in detail. At time may ask you relevant investigations if necessary. All information will be used to determine exact underlying cause of problem. Depending upon cause will prescribe you treatment. Scar on face due to bacterial infections Pic is not clear, plz visit for proper opinion I have a history of recurring yeast and bacterial vaginosis infections. Tab metrogyl 500 mg twice a day x 5 days and tab fluconazole 150 mg three doses alternate days I suffering from bacterial infections in my shaving area or too much acne problem. Fudic cream twice a day My child verry high cough and fever in cold sesion try to much doctor but result is no . It's will be countiue cough and fever it's good to be only antiboitic Antibiotics are required if bacterial infections. Consult child specialist What are use mega-cv dry syrup Child are not drinking milk Mega CV is an antibiotic used to treat bacterial infections Sir which medication can we use to fast healing the wound such as minor cut,bacterial infections just apply Neomycin cream locally